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TranscriptomicsDynamic developmental signaling logic underlying lineage bifurcations during human endoderm induction and patterning from pluripotent stem cells [Endoderm RNA-seq and ChIP-seq data sets]
Unraveling complex signaling programs animating developmental lineage-decisions is pivotal to differentiate human pluripotent stem cells (hPSC) into pure populations of desired lineages for regenerative medicine. Developmental signals are strikingly temporally dynamic: BMP and Wnt initially specify ...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-52657 | biostudies-arrayexpress
ProteomicsMaternal immune activation perturbs intestinal niche through microbial glycerophospholipids and drives offspring behavioral abnormalities
Using a mouse MIA model induced by prenatal exposure to Toxoplasma gondii soluble tachyzoite antigen (STAg), we reveal that maternal gut dysbiosis, characterized by increased Firmicutes and Actinobacteria, drives offspring behavioral deficits. This dysbiosis disrupts intestinal barrier integrity and...
ORGANISM(S): Mus Musculus 
2026-03-04 | PXD075246 |
ProteomicsHuman colon cancer HCT116 cell LC/MSMS
Mitosis deregulation is a key event during carcinogenesis. Alternative splicing spectrum alteration plays a critical role during mitosis shift. However, the molecules responsible for dysregulated alternative splicing driving carcinogenetic mitosis remain poorly defined. Here, we demonstrate that can...
ORGANISM(S): Homo Sapiens 
2020-03-30 | PXD018242 |
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