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MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsUbiquitination regulation of streptococcus agalactiae infection in dairy cow mammary epithelial cells
A total of 5239 proteins were identified in this study, of which 4601 proteins contained quantitative information. If 1.5 times is used as the change threshold and t-test p-value<0.05 as the standard, then among the quantified proteins, the expression of 325 proteins in the T/C comparison group will...
ORGANISM(S): Bos taurus (Bovine) 
2022-10-13 | PXD028659 | Pride
Potential biomarkers Ubiquitination Bovine mammary epithelial cells Streptococcus agalactiae Proteomic analysis 
ProteomicsProteomic analysis of bovine mammary epithelial cells after in vitro incubation with S. agalactiae: potential biomarkers
Streptococcus agalactiae is one of the causative agents of subclinical mastitis, a common disease of dairy cows that causes great economic losses in the industry worldwide. It is thought that pathology is mainly due to infammatory damage of bovine mammary epithelial cells (bMECs); however, the mec...
ORGANISM(S): Bos taurus (Bovine) 
2022-10-13 | PXD028585 | Pride
Potential biomarkers Bovine mammary epithelial cells Streptococcus agalactiae Proteomic analysis 
ProteomicsRewiring the metabolic network to increase docosahexaenoic acid productivity in Crypthecodinium cohnii by fermentation supernatant-based adaptive laboratory evolution
To overcome the inhibition caused by the fermentation supernatant in the late fermentation stage of docosahexaenoic acid (DHA)-producing Crypthecodinium cohnii, fermentation supernatant-based adaptive laboratory evolution (FS-ALE) was conducted. The cell growth and DHA productivity of the evolved st...
ORGANISM(S): Crypthecodinium Cohnii 
2021-11-27 | PXD030028 |
ProteomicsIntegrated Analysis of Laminin Subunit Beta 1 Impact on Subchorionic Hemorrhage: Insights into Inflammation and Thrombosis Pathways
Subchorionic hemorrhage (SCH) is characterized by a fluid-filled hypoechoic area in early pregnancy. This study investigates how laminin subunit β1 (LAMB1) modulates type III collagen (COL3A1) and Rac family small GTPase 1 (RAC1) in SCH coagulation and immunity.
ORGANISM(S): Homo Sapiens 
2025-12-03 | PXD071504 |
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