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ProteomicsIdentification of zein proteome by multi-enzyme digestion
Zeins are a class of prolamine proteins extracted from maize, and are extensively used in the food and pharmaceutical industries. Therefore, characterization of its components is essential for quality control and safety evaluation. However, zein proteins have low abundance of the trypsin targets lys...
ORGANISM(S): Zea Mays 
2019-07-25 | PXD014743 |
ProteomicsIntegrated proteomic and metabolomic profiling the global response of rat glioma model to temozolomide treatment
Temozolomide (TMZ) is the first-line chemotherapeutic drug for glioblastoma treatment. It can induce O6-methylguanine DNA lesions, lead to prolonged G2–M arrest and ultimately cell death. However, the molecular response involved in TMZ inhibiting tumor growth has not been fully elucidated. In this s...
ORGANISM(S): Rattus Norvegicus 
2019-05-09 | PXD013790 |
Proteomicsmouse liver kidney LC-MS/MS - Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney
Triptolide (TP), the major active component in Tripterygium wilfordii Hook. f. (Tripterygium Glycosides), contributes to treat rheumatoid arthritis and anticancer activities. However, the organ toxicity, especially nephrotoxicity and hepatotoxicity limit its clinical application. To fully understand...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-05 | PXD005434 | Pride
Triptolide  proteomics  kidney  liver  fatty acids  2d-lc-ms/ms  organ toxicity 
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