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MetabolomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis

Background: Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host...

2026-02-25 | MTBLS13930 | MetaboLights
TranscriptomicsAnalyses of mIRNA transcript level following exposure to triptolide
Analyses of mirna transcript levels following exposure to the drug triptolide in vitro and prodrug minnelide in xenograft pancreatic tumor mouse models. Response of pancreatic adenocarcinoma cell lines to minelide in vitro and exposure to its prodrug triptolide in SCID mouse tumors derived from the ...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-46188 | biostudies-arrayexpress
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [Mouse lung macrophages]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074740 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
TranscriptomicsWhole genome analysis in A549 cells treated for short incubation periods with various concentrations of triptolide
The purpose of this study was to identify the genes primarily affected by a short treatment of A549 cells with grading concentrations of the natural compound triptolide. The cells were exposed to this molecule before RNA was extracted, then used for whole human genome microarray experiments. 12 samp...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-16760 | biostudies-arrayexpress
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [iBDMDs]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074476 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
TranscriptomicsThe genes affected by Triptolide in activated mouse primary T cells
Triptolide possesses immunosuppressive activity and its efficacy is commonly believed to be related to the suppression of T cells. However, the underlying mechanism is still not well documented and most of the previous study adopted tumor cell lines of immune system as model cells in mechanism resea...
ORGANISM(S): Mus musculus 
2012-12-29 | E-GEOD-32315 | biostudies-arrayexpress
TranscriptomicsExpression data from treatment of actinomycin D and triptolide on MCF7 cells
Expression data from treatment of actinomycin D (2.5uM) and triptolide (500 nM) on MCF7 cells for 2, 4 and 6 hours. We used microarrays to explore the mechanism of triptolide action. MCF7 cells were treated with actinomycin D or triptolide for 2, 4 and 6 hours, RNA was extracted and hybridization on...
ORGANISM(S): Homo sapiens 
2011-10-17 | E-GEOD-28662 | biostudies-arrayexpress
TranscriptomicsExpression data for HUVSMC treated with Triptolide
Transcription of mRNA in mammalian is mainly performed by RNA polymerase II (PolII). POLRMT is responsible for the production of cytoplasmic and nuclear form of mitochondrial RNA polymerase. The former (mtRNAP) participates in transcription of RNA in the mitochondria while the latter (spRNAP-IV) is ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-28502 | biostudies-arrayexpress
Proteomicsmouse liver kidney LC-MS/MS - Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney
Triptolide (TP), the major active component in Tripterygium wilfordii Hook. f. (Tripterygium Glycosides), contributes to treat rheumatoid arthritis and anticancer activities. However, the organ toxicity, especially nephrotoxicity and hepatotoxicity limit its clinical application. To fully understand...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-05 | PXD005434 | Pride
Triptolide  proteomics  kidney  liver  fatty acids  2d-lc-ms/ms  organ toxicity 
GenomicsThe mechanism of reproductive toxicity induced by Triptolide was revealed by epitranscriptomics
The mechanism of reproductive toxicity induced by Triptolide was revealed by epitranscriptomics
PRJNA1427133 | ENA
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