Sort   by:  
 Page size 
UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Not available
S-EPMC6366813 | biostudies-literature
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
UnknownBRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
Not available
S-EPMC4356711 | biostudies-literature
MetabolomicsMetabolomic Responses of Arabidopsis Suspension Cells to Bicarbonate under Light and Dark Conditions
Global CO2 level presently recorded at 400 ppm is expected to reach 550 ppm in 2050, an increment likely to impact plant growth and productivity. Using targeted LC-MS and GC-MS platforms we quantified 229 and 29 metabolites, respectively in a time-course study to reveal short-term responses to diffe...
2017-04-25 | MTBLS311 | MetaboLights
MetabolomicsThe genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

Cyclic peptides are reported to have antibacterial, antifungal and other bioactivities. Orbitides are a class of cyclic peptide that are small, head-to-tail cyclized, composed of proteinogenic amino acids, and lack disulfide bonds; they are also known in several genera of the plant family Rutacea...

2020-10-14 | MTBLS1963 | MetaboLights
UnknownDown-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
Not available
S-EPMC3436579 | biostudies-literature
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in hu...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD004746 | Pride
Human Mhc Mantle cell lymphoma Antigen presentation Ltq orbitrap elite 
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in huma...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005704 | Pride
Human Antigen presentation Ltq orbitrap elite Mhc class i 
ProteomicsSpectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from 1-3, and subunits. Here, we isolate distinct GABAARs from the brain and interrogate their composition using quantitative pr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD038703 | Pride
Ais Gaba a receptors Spectrins 
Sort   by:  
 Page size