Sort   by:  
 Page size 
TranscriptomicsMitochondrial functional aberrations in a mouse model of non-ischemic heart failure
We characterized the metabolic and cardiac mitochondrial function in a mouse model of non-ischemic HF. Inhibition of nitric oxide synthesis and hypertension, which often present together, are two important risk factors in human non-ischemic HF. Compared with L-NAME L-NG-Nitroarginine methyl ester (L...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-72132 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
TranscriptomicsDefining the Myb Transcriptional Program Controlled by via Genome-wide Chromatin Occupancy and Expression Analyses
We used the ERMYB cell line (Hogg et al., Oncogene 15, p2885-2898, 1997) as our model system to identify genes regulated by Myb using whole genome microarray expression profiling. ERMYB is a myeloid progenitor cell line derived by transformation of primary cells by an activated form of Myb (CT3-Myb)...
ORGANISM(S): Mus musculus 
2011-02-23 | E-GEOD-22486 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in293T cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic 293T cells. The cells were then subjected to transcripome profili...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-56945 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in CN-LM1a cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic CN-LM1a cells. The cells were then subjected to transcripome prof...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-56947 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2-shDicer cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 shDicer cells. The cells were then subjected to transcrip...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-56950 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to transcripome prof...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49611 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of ZNF395 knock-down in MDA-LM2-shTARBP2 cell-line
shRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of ZNF395 resulted in a significant up-regulation in several key oncogenes. ZNF395 was knocked-down, via expression of short-hairpin RNAs targeting its transcript. The cells were then subjected to transcripome pro...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49613 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line [stability experiment]
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant increase in the stability of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to whole...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49612 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in Dicer-null MEFs
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic Dicer-null cells. The cells were then subjected to transcripome p...
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-56949 | biostudies-arrayexpress
Sort   by:  
 Page size