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MetabolomicsEmerging mechanisms and promising approaches in pancreatic cancer metabolism.

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to biosynthesis, energy intake and redox needs through metabolic reprogramming to tolerate nutrient deficiency and hypoxic ...

2025-03-26 | MTBLS12204 | MetaboLights
MetabolomicsCharacteristics of steroid hormones in systemic lupus erythematosus revealed by GC/MS-based metabolic profiling

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a remarkable predominance in female, suggesting that steroid hormones may be involved in the pathogenesis. Herein, more than 70 kinds of steroids in urine were detected by gas chromatography/mass spectrometry (GC/MS) to reve...

2023-07-28 | MTBLS7766 | MetaboLights
UnknownCOVID-19-Related Rumor Content, Transmission, and Clarification Strategies in China: Descriptive Study.
Not available
S-EPMC8709421 | biostudies-literature
TranscriptomicsmRNA and sRNA Transcriptomes Reveal Insights into Dynamic Homoeolog Regulation for Allopolyploid Heterosis in Nascent Hexaploid Wheat
Nascent allohexaploid wheat may represent the initial genetic state for the evolution and domestication of common wheat, which arose by combining the AB genomes of tetraploid Triticum turgidum with the D genome from Aegilops tauschii and out-competed its parents in growth vigor and adaptability. To ...
ORGANISM(S): Triticum dicoccon 
2014-10-20 | E-GEOD-56587 | biostudies-arrayexpress
ProteomicsClinicopathological Observation and Initial Exploration of Characteristic Biomarkers in Apocrine Breast Carcinoma
Perform proteomic profiling comparing triple-negative apocrine carcinoma (TNAC) and luminal androgen receptor-type triple-negative breast cancer (LAR-TNBC) to elucidate their molecular distinctions and validate TNAC as a distinct entity separate from LAR-TNBC.
ORGANISM(S): Homo Sapiens 
2026-01-26 | PXD073549 |
ProteomicsASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis
Despite advances in comprehensive gastric cancer (GC) therapies, the prognosis of patients with liver metastasis remains poor. Identifying potential molecular targets for GC liver metastasis (GCLM) may provide new treatment avenues. Initially, clinical samples from patients with GCLM were analyzed t...
ORGANISM(S): Homo Sapiens 
2025-10-09 | PXD069269 |
ProteomicsSerum proteomic analysis identifies SAA1, FGA，SAP and CETP as new biomarkers for Eosinophilic granulomatosis with polyangiitis
Our findings suggest that DIA combined with PRM mass spectrometric method was effective in identifying and validating the candidate biomarkers for several diseases including EGPA diagnosis. We have discovered and validated three new potentially serum biomarkers FGA, SAP and CETP for discriminating E...
ORGANISM(S): Homo Sapiens 
2022-02-15 | PXD029759 |
ProteomicsLactylation contributes to colorectal carcinogenesis
To reveal the lactylated proteins in CRC, we analyzed the lactyl-proteome from seven paired biopsies from CRC patients by using mass spectrometry analysis (LC-MS/MS). Meanwhile, we used LC-MS to identify Kla and Kac substrates upon HCT116 cells.
ORGANISM(S): Homo Sapiens 
2022-10-27 | PXD037744 |
ProteomicsDirect Evolution of Adeno-Associated Virus 5 Capsid Enables Specific Liver Tropism
Gene therapy has been thriving in recent years, as featured by general triumphs in several clinical trials to treat hemophilia. It highlights the significance of AAV mediated gene delivery to liver. AAV5 is a unique serotype with low neutralizing antibody prevalence. In this study, we generated an A...
ORGANISM(S): Adeno-associated Virus - 5 
2022-04-01 | PXD032891 |
ProteomicsMTH1's role in platelet function
MTH1 knockout mice were utilized to evaluate its role in platelet mitochondrial function and thrombosis
ORGANISM(S): Mus Musculus 
2023-04-14 | PXD041528 |
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