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ProteomicsThe Matrisome Reveals the Characterization of Skin Keloid Microenvironment
Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis. In this study, the dermal EC...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD019052 |
ProteomicsASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice
During spermiogenesis, nuclear remodeling occurs where histones are initially replaced by transition proteins (TNPs) and subsequently by protamines, a process essential for sperm maturation. Although the degradation of histones and TNPs is thought to be essential for sperm nuclear remodeling, the un...
ORGANISM(S): Mus Musculus 
2025-11-19 | PXD070974 |
ProteomicsProteomics Characterization of COVID-19 lung tissues
The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underly...
ORGANISM(S): Homo Sapiens 
2020-03-19 | PXD018094 |
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