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ProteomicsThe role of Cdk1-cyclin B in G1/S transition revealed by chemical genetic inhibition of Cdc7
Entry of mammalian cells into DNA synthesis (S-phase) represents a key event in cell division. According to the current cell cycle models, the Cdc7 kinase represents the essential and rate-limiting trigger of DNA replication, acting together with the cyclin-dependent kinase Cdk2. Using chemical gene...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-11 | PXD025625 | Pride
Cdk1-cyclinb G1/s transition Cdc7 Dna replication 
TranscriptomicsEvidence that cryptic promoters occur extensively throughout the Saccharomyces cerevisiae genome
Microarray analysis was used to identify all cryptic promoters in the S. cerevisiae genome that are activated in spt6 and spt16 mutants. These experiments showed that cryptic initiation is widespread, occurring in approximately 1,000 genes. We generated 2 microarray profiles from fluor-rev...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-16 | E-GEOD-12272 | biostudies-arrayexpress
UnknownCase report: Successful immunomodulators combined with electromagnetic field therapy in a patient with methazolamide-induced Steven Johnson syndrome/toxic epidermal necrolysis overlap.
Not available
S-EPMC10248229 | biostudies-literature
ProteomicsPatient datasets for: A large peptidome dataset improves HLA class I epitope prediction across most of the human population
Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CH, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, Justeson S, Stevens J, Lane WJ, Eisenhaure T, Zhang GL, Clauser KR, Hacohen N, Carr SA, Wu CJ, Keskin DB. Nature Biotechnolog...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-09 | MSV000084442 | MassIVE
ProteomicsMono-allelic datasets for: A large peptidome dataset improves HLA class I epitope prediction across most of the human population
Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CH, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, Justeson S, Stevens J, Lane WJ, Eisenhaure T, Zhang GL, Clauser KR, Hacohen N, Carr SA, Wu CJ, Keskin DB. Nature Biotechnolog...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-06 | MSV000084172 | MassIVE
TranscriptomicscaArray_EXP-578: Gene Expression Profiles of Pediatric B-Precursor High-Risk Acute Lymphoblastic Leukemia (COG Study AALL0232 - Cohort 1).
This experiment comprises 283 CEL files generated on the Affymetrix U133 Plus 2.0 gene expression microarray platform, using patient peripheral blood and bone marrow samples from the first cohort of patients accrued to Children's Oncology Group Study AALL0232. No clinical covariate data is provided ...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-68790 | biostudies-arrayexpress
ProteomicsDesign, Implementation and Multisite Evaluation of a System Suitability Protocol for the Quantitative Assessment of Instrument Performance in Liquid Chromatography-Multiple Reaction Monitoring-MS (LC-MRM-MS)
Multiple reaction monitoring (MRM) mass spectrometry coupled with stable isotope dilution (SID) and liquid chromatography (LC) is increasingly used in biological and clinical studies for precise and reproducible quantification of peptides and proteins in complex sample matrices. Robust LC-SID-MRM-MS...
ORGANISM(S): Bos Taurus 
2018-07-23 | PXD010535 | panorama
ProteomicsRegulation of AMP synthesis by a KCTD13 ubiquitin ligase connects 16p11.2 deletion syndrome to a metabolic disorder with autistic features
Madison JM, Duong K, Vieux EF, Iqbal S, Requadt E, Udeshi ND, Fereshetian S, Lewis MC, Gomes AS, Pierce KA, Platt RJ, Zhang F, Campbell AJ, Lal D, Wagner FF, Clish CB, Carr SA, Scolnick EM, Cottrell JR. 2020. Genetic variation of KCTD13 at the 16p11.2 deletion locus and of CUL3 are linked with autis...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-29 | MSV000085846 | MassIVE
Genomics5-hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells.
Hydroxymethylcytosine (5hmC) was recently found to be abundantly present in certain cell types including embryonic stem cells. The function of 5hmC is poorly understood. Here we have generated a genome-wide map of 5hmC in human embryonic stem cells (hESCs) by hydroxymethyl-DNA immunoprecipitation fo...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-27627 | biostudies-arrayexpress
ProteomicsTime-resolved proximity labeling of protein networks associated with ligand-activated EGFR
Ligand binding to the EGF receptor (EGFR) initiates signal transduction and endocytosis of the receptor. The mechanisms of endocytosis and regulation of signaling by endocytosis are poorly understood. Here, we combined peroxidase-catalyzed proximity labeling, isobaric peptide tagging and quantitativ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-04 | PXD030072 | Pride
Proteomics analysis Tmt Endocytosis Tfg Egfr Proximity labeling 
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