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ProteomicsDiscovery of potential candidate proteins reprogramming spinal cord derived astrocytes into neurons by proteomic analysis
Spinal cord injury (SCI) is a common but devastating trauma of the central nerve system. In this study, we reprogrammed cultured spinal-cord reactive astrocytes into neurons by Neurod1 expression. The mechanism of programmed conversion from astrocytes to neurons has not been clarified yet. Thus, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD016097 | Pride
Spinal cord injury Astrocytes Neurons Label-free proteomic analysis Reprogramming 
ProteomicsStructural Alternation in Heat Shock Proteins of Activated Macrophages
The inflammatory response of macrophages is an orderly and complex process under strict reg-ulation accompanied by drastic changes in morphology and functions. It is predicted that pro-teins will undergo structural changes during these finely regulated processes. However, changes in structural prote...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029672 | Pride
Structural proteomics  raw264.7  lps  lip-ms  hsp60 
ProteomicsMultiomics analysis of a DNAH5-mutated PCD organoid model revealed the key role of the TGF-β/BMP and Notch pathways in epithelial differentiation and the immune response in DNAH5-mutated patients
Dynein axonemal heavy chain 5 (DNAH5) is the most mutated gene in primary ciliary dyskinesia (PCD), leading to abnormal cilia ultrastructure and function. Few studies have revealed the genetic characteristics and pathogenetic mechanisms of PCD caused by DNAH5 mutation. Here, we established a child P...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038024 | Pride
Primary ciliary dyskinesia Immune response Airway organoid Dnah5 Multiomics analysis 
GenomicsDNA methylome patterns of zebrafish cells under cold pressure
In this study, MeDIP-seq and RNA-seq were performed to reveal a genome-wide methylation profile of zebrafish (Danio rerio) embryonic fibroblast cell line (ZF4) and its variation under cold environment.This study puts a new insight into the genome-wide epigenetic regulation under cold environment. ZF...
ORGANISM(S): Danio rerio 
2016-07-30 | E-GEOD-71567 | biostudies-arrayexpress
Proteomics,MultiomicsMudPIT analyses of the proteins co-purified with Halo-tagged Human HNRNP proteins from HEK293T cells with and without RNAse
Plasmids encoding full-length open-reading frames (ORF) of heterogeneous nuclear ribonucleoproteins fused to a HaloTag (HT) were transfected in human HEK293T cells in biological duplicates. The expressed proteins were: HNRNPA0 (NM_006805; NP_006796.1), HNRNPA1 (NM_002136; NP_002127.1), HNRNPD (NM_00...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-18 | MSV000079669 | MassIVE
GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
TranscriptomicsCRISPR screen exploring resistance to AKTi (Capivasertib) in ER+ Breast Cancer in MCF7, T47D and CAMA-1 cell lines
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16438 | biostudies-arrayexpress
ProteomicsNEAT1 Regulates BMSCs Aging Through Disruption of FGF2 Nuclear Transport
Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to eluc...
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059860 |
ProteomicsIntegrative Proteomics and N-Glycoproteomics Reveals the Synergistic Anti-tumor Effects of Aspirin and Gemcitabine-based Chemotherapy on Pancreatic Cancer Cells
Based on an integrated multi-omics based on quantitative N-glycoproteomes analysis strategy, we investigated their synergistic anti-tumor effects and explored the potential molecular mechanisms and biological functions underlying their inhibitory effects on the development of pancreatic cancer.
ORGANISM(S): Homo Sapiens 
PXD041445 |
ProteomicsProteomic analysis of Rhitymna verruca
Rhitymna verruca is a large nocturnal wandering spider and an important natural predator of agricultural and forestry pests, with its venom playing a key role in prey capture. However, systematic studies on the composition of its venom remain scarce. In this study, we performed an integrated analysi...
ORGANISM(S): Unclassified Sparassidae 
2025-10-29 | PXD070066 |
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