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MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
TranscriptomicsRNA-seq comparison of Clostridium acetobutylicum wild-type and pks mutant under batch fermentation conditions.
The goal of this experiment is compare gene expression profiles between C. acetobutylicum wild-type and pks mutant strains to determine which genes might be under the control of self-produced polyketides. Samples for RNA-seq comparison were taken from batch fermentation cultures 26 hours post-inocul...
ORGANISM(S): Clostridium acetobutylicum 
2017-09-27 | E-MTAB-6019 | biostudies-arrayexpress
MetabolomicsBiosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria
A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemica...
2017-07-18 | MTBLS454 | MetaboLights
TranscriptomicsTranscriptome of iPSC-derived Neural Cells with Heterozygous Knockout in CHD8
CHD8, encoding Chromodomain helicase DNA binding protein 8, is a top autism spectrum disorders (ASDs) risk gene. To better understanding the molecular links between CHD8 functions and ASD, we have applied the CRISPR/Cas9 technology to knockout one copy of CHD8 in induced pluripotent stem cells (iPSC...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-71594 | biostudies-arrayexpress
Genomicsena-DATASET-BIOPIC-06-06-2018-15:24:14:117-163 - samples
bulk RNA-seq data of the 5 HCC patinets. Single cell RNA seq data of these patients was under the accession number EGAD00001003337
EGAD00001004148 | EGA
Genomicsena-DATASET-BIOPIC-06-06-2018-15:55:49:835-165 - samples
bulk Exome-seq data of the 5 HCC patinets. Single cell RNA seq data of these patients was under the accession number EGAD00001003337
EGAD00001004149 | EGA
Genomicsena-DATASET-BIOPIC-16-05-2017-14:34:15:534-498 - samples
T cells isolated from peripheral blood, tumors and adjacent normal tissues from six hepatocellular carcinoma patients. SmartSeq2 and Tang2009 protocol were used to amplify RNA from single T cells. High depth enables simultaneously expression profiling and TCR assembling.
EGAD00001003337 | EGA
GenomicsSingle-cell RNA sequencing on 5063 single T cells isolated from peripheral blood, tumour and adjacent normal tissues from six hepatocellular carcinoma patients.
Single-cell RNA sequencing on 5063 single T cells isolated from peripheral blood, tumour and adjacent normal tissues from six hepatocellular carcinoma patients. The transcriptional properties of these individual cells, coupled with the assembled T cell receptor (TCR) sequences, were used to delineat...
EGAS00001002072 | EGA
GenomicsPeking University BIOPIC Data Access Committee (PUBDAC).The DATA ACCESS AGREEMENT is provided at https://github.com/zhangyybio/single-T-cell-data-access. Applicants can request access to the data by directly downloading it or by sending an email to cancerpku@pku.edu.cn. The process that is used to approve an application includes verifying the institution, participants and research purposes of the application. In general this process will take about two weeks. In principal, any academic research
Data Access Committee EGAC00001000551
EGAC00001000551 | EGA
ProteomicsIntegrated Proteogenomic Characterization of Medullary Thyroid Carcinoma
Global proteome data for 102 MTC samples, and phosphoproteome data for 74 MTC samples
ORGANISM(S): Homo Sapiens 
2022-04-01 | PXD032887 |
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