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UnknownSystems pharmacology approaches decipher the anti-cancer efficacy of ethnopharmacological agents in hepatocellular carcinoma.
Not available
S-EPMC12711885 | biostudies-literature
UnknownHOPX regulates the invasion and migration abilities of hepatocellular carcinoma by targeting SNAIL
Not available
S-EPMC12350657 | biostudies-literature
TranscriptomicsPlasma miRNA profile as a predictor for early virological response of interferon treatment in chronic hepatitis B patients
To find novel circulating markers associated with prognosis of interferon therapy,We performed microarray analysis of plasma samples in 94 chronic hepatitis B patients Ninety four HBV patients, who underwent PEG-IFN or conventional interferon treatment were enrolled. Their plasma samples before trea...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-29911 | biostudies-arrayexpress
ProteomicsThe changes of Proteomeand Protein Phosphorylation reveals the protective roles of exogenous nitrogen in alleviating cadmium toxicityin poplar plants
Phytoremediation soil polluted by heavy metal has been drawn on a worldwide attention from human society. However, how to improve the efficiency of plant remediation of soil contaminated by cadmium remains unknown. Previous studies showed that nitrogen (N) significantly enhanced cadmium uptake in po...
ORGANISM(S): Populus yunnanensis 
2020-05-26 | PXD013360 | Pride
Plants Exogenous nitrogen Phosphorylation 
ProteomicsComparative proteomic analysis of pepper (Capsicum annuum L.) seedlings under selenium stress
Selenium (Se) is an essential trace element for human and animal health. Se fertilizer has been used to increase the Se content in crops to meet the Se requirements in humans and animals. To address the challenge of Se poisoning in plants, the mechanisms underlying Se-induced stress in plants must b...
ORGANISM(S): Capsicum annuum 
2019-09-16 | PXD013257 | Pride
Selenium stress Capsicum annuum l. Seedlings Proteomic analysis 
ProteomicsProteomics and network pharmacology of Ganshu Nuodan capsules in the prevention of alcoholic liver disease
A mouse model of acute alcohol liver disease (ALD) induced by intragastric administration of 50% alcohol was used to evaluate the hepatoprotective effect of Ganshu Nuodan. The chemical constituents of Ganshu Nuodan were comprehensively identified by UPLC-QTOF/MS, and then its pharmacodynamic materia...
ORGANISM(S): Mus Musculus 
2023-09-08 | PXD045221 |
ProteomicsLoss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella
Aberrant sperm flagella impair sperm motility and cause male infertility, yet the genes which have been identified in multiple morphological abnormalities of the flagella (MMAF) can only explain the pathogenic mechanisms of MMAF in a small number of cases. Here, we identify and functionally characte...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD011730 | Pride
Mutation Sperm flagella Morphological abnormalities Proteomics analysis 
ProteomicsThe Role of CDYL-Regulated Crotonylation of RPA1 in Homologous Recombination-Mediated DNA Repair
Lysine crotonylation (Kcr) is a recently-identified protein short-chain acylation. We have previously reported that chromodomain Y-like transcription corepressor CDYL acts as a crotonyl-CoA hydratase and negatively regulates histone Kcr. However, the global crotonylome of CDYL-regulated Kcr on non-h...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD013616 | Pride
Cdyl crotonylation  rpa1 dna repair 
ProteomicsLabel-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line
Hepatitis B virus (HBV) infection is a major health problem worldwide. Recent evidence suggests that various viruses can manipulate the infection process by secretion of specific viral and cellular components into exosomes, small nanometer-sized (30-150 nm) vesicles secreted from various cells. Howe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080718 | MassIVE
ProteomicsComparative proteomic analysis provides novel insights into the complex responses to Pseudoperonospora cubensis infection of cucumber (Cucumis sativus L.)
Cucumber (Cucumis sativus L.) is an economically important vegetable crop distributed in over 80 countries. Downy mildew (DM) caused by the obligate oomycete Pseudoperonospora cubensis is especially destructive in cucumber production. So far, few studies on the changes in proteomes during the P. cub...
ORGANISM(S): Cucumis sativus 
2019-11-12 | PXD010844 | Pride
Downy mildew Cucumber Terpenoid backbone biosynthesis Pathogen resistance Differential accumulated protein Pseudoperonospora cubensis 
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