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ProteomicsThe Role of CDYL-Regulated Crotonylation of RPA1 in Homologous Recombination-Mediated DNA Repair
Lysine crotonylation (Kcr) is a recently-identified protein short-chain acylation. We have previously reported that chromodomain Y-like transcription corepressor CDYL acts as a crotonyl-CoA hydratase and negatively regulates histone Kcr. However, the global crotonylome of CDYL-regulated Kcr on non-h...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD013616 | Pride
Cdyl crotonylation  rpa1 dna repair 
ProteomicsNuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues ...
ORGANISM(S): Homo Sapiens 
2022-01-17 | PXD031029 |
GenomicsBiological significance of CDYL in endometrial receptivity
Biological significance of CDYL in endometrial receptivity
PRJNA592906 | ENA
GenomicsChIP-seq data of CDYL in mouse dorsal root ganglia
ChIP-seq data of CDYL in mouse dorsal root ganglia
PRJNA789177 | ENA
GenomicsAlteration of gene expression in E11.5 XY Cdyl deficient gonadal somatic cells
Alteration of gene expression in E11.5 XY Cdyl deficient gonadal somatic cells
PRJNA938426 | ENA
UnknownCdyl: a new transcriptional co-repressor.
Not available
S-EPMC1326355 | biostudies-literature
GenomicsCDYL ChIP-Seq in mouse hippocampus
Here we report that the epigenetic factor Chromodomain Y-like (CDYL) protein is a critical regulator for the initiation and maintenance of activity-dependent intrinsic neuroplasticity. Genome-wide ChIP-sequencing analysis revealed that CDYL regulates multiple neuronal functional pathways including v...
ORGANISM(S): Mus musculus 
2017-06-25 | GSE96721 | GEO
GenomicsChIP-seq data of CDYL in mouse dorsal root ganglia
We report that the epigenetic factor CDYL is crucial for pain processing. CDYL downstreams in mouse dorsal root ganglia (DRG) are mostly associated with neurological functions, including chemical synaptic transmission, regulation of membrane potential and ion transport. CDYL facilitates H3K27me3 dep...
ORGANISM(S): Mus musculus 
2022-02-08 | GSE190751 | GEO
TranscriptomicsBiological significance of CDYL in endometrial receptivity
Impaired endometrial receptivity is one of the major causes of recurrent implantation failure (RIF), and the underlying molecular mechanism has not been fully elucidated. We demonstrated that Chromodomain Y like (CDYL) was highly expressed in the endometrium at mid-secretory phase during the normal ...
ORGANISM(S): Homo sapiens 
2020-09-28 | GSE141239 | GEO
GenomicsChromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin [ChIP-seq]
Chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin [ChIP-seq]
PRJNA1156625 | ENA
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