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GenomicsGenome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer
The estrogen receptor alpha (ERa) drives the growth of two-thirds of all breast cancers. Endocrine therapy impinges on estrogen-induced ERa activation to block tumor growth. However, half of ERa-positive breast cancers are tolerant or acquire endocrine therapy resistance. Here we demonstrate that br...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-37323 | biostudies-arrayexpress
GenomicsIntegrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus
Genome-wide association studies (GWAS) are identifying genetic predisposition to various diseases. The rs1859962 single nucleotide polymorphism (SNP) part of the 17q24.3 locus is a risk factor for prostate cancer (PCa). It defines a 130kb linkage disequilibrium (LD) block that lies in a ~2Mb gene de...
ORGANISM(S): Homo sapiens 
2012-06-03 | E-GEOD-35829 | biostudies-arrayexpress
Proteomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced H3K9bhb Levels and Gene Expression Regulation
Although the functions of protein Kbhb have been widely studied in animal cells, however, the identification and functional characterization of this modification in plants remain unclear. Here, we identified 2,159 Kbhb sites on 1,128 proteins in rice flowers by Kbhb-proteomic analyses, serving as a ...
ORGANISM(S): Oryza sativa (Rice) 
2025-07-05 | PXD051126 | Pride
Lysine β-hydroxybutyrylation 
TranscriptomicsNext generation sequencing of Coccinella septempunctata L. with non-diapause, diapause, and diapause-terminated states
The most common ladybird beetle, Coccinella septempunctata L., is an excellent predator of crop pests such as aphids and white flies, and it shows a wide range of adaptability, a large appetite and a high reproductive ability. In this study, we collected female adults in three different states, i.e...
ORGANISM(S): Coccinella septempunctata 
2016-06-01 | E-GEOD-75645 | biostudies-arrayexpress
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
GenomicsChIP-seq of H3K27ac in lung cancer and endometrial carcinoma cells
Using H3K27ac ChIP-seq profile to map active enhancers in lung cancer and endometrial carcinoma cells ChIP-seq of H3K27ac was done in lung adenocarcinoma cell lines (NCI-H358 and NCI-H2009), squamous cell lung carcinoma cell lines (HCC95) and endometrial carcinoma cell lines (Ishikawa)
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-66992 | biostudies-arrayexpress
UnknownEvaluation of Differentially Expressed Genes in Leaves vs. Roots Subjected to Drought Stress in Flax (Linum usitatissimum L.).
Not available
S-EPMC10419004 | biostudies-literature
UnknownComprehensive Analysis of Differentially Expressed Genes and Epigenetic Modification-Related Expression Variation Induced by Saline Stress at Seedling Stage in Fiber and Oil Flax, Linum usitatissimum L.
Not available
S-EPMC9370232 | biostudies-literature
UnknownLight-weight reference-based compression of FASTQ data.
Not available
S-EPMC4459677 | biostudies-literature
Proteomicsproteomic investigation of ovarian follicular fluid
To investigate the relationship between differentially expressed proteins in human ovarian follicular fluid representing oocyte maturation and quality.
ORGANISM(S): Homo Sapiens 
2021-07-26 | PXD027577 |
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