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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
UnknownCanonical Correlation Analysis of Imaging Genetics Data Based on Statistical Independence and Structural Sparsity.
Not available
S-EPMC9675402 | biostudies-literature
TranscriptomicsExpression data from rice seedlings of wild type and the CHR729 mutant
In order to study the function of CHR729 in rice, the T-DNA insertion mutant of CHR729 was obtained and analysed. Total RNAs were extracted from 11-day-old seedlings of both wild type (Hwayoung) and CHR729 mutant plants. Affymetrix GeneChip® Rice Genome Array hybridization was performed with three b...
ORGANISM(S): Oryza sativa Japonica Group 
2010-11-04 | E-GEOD-25073 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K4me3 and H3K27me3 in HY(Hwayong) and chd1(chr729) rice.
We report the application of CHIP-seq technology for high-throughput profiling of histone modifications in HY(Hwayong) and chd1(chr729). By obtaining about 12 million reads of sequence from chromatin immunoprecipitated DNA, we generated genome-wide H3K4me3 and H3k27me3 maps of HY(Hwayong) and chd1(c...
ORGANISM(S): Oryza sativa Japonica Group 
2012-03-10 | E-GEOD-30490 | biostudies-arrayexpress
TranscriptomicsProfiling the target genes for ZIP repressor in MCF-7
Using ChIP-DSL technology from Aviva Systems Biology to find out the whole genome targets for ZIP transcription repressor We analyzed arrays using specific ZIP antibody and negative control to acquire the enriched ratio of each gene
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-13905 | biostudies-arrayexpress
TranscriptomicsProfiling the target genes for LSD1, MTA1, MTA2, and MTA3 in MCF-7
Using ChIP-DSL technology from AVIVA SYSTEMS BIOLOGY to find out the whole genome targets for LSD1, MTA1, MTA2, and MTA3 We analyzed arrays using antibodies against LSD1, MTA1, MTA2, or MTA3 and negative control to acquire the enriched ratio of each gene.
ORGANISM(S): Homo sapiens 
2009-08-21 | E-GEOD-14260 | biostudies-arrayexpress
ProteomicsNucleation of DNA Repair Factors by FOXA1 Links DNA Demethylation and Transcriptional Pioneering
We report that the winged helix transcription factor FOXA1 is unexpectedly associated with components of single and double stranded-DNA repair complexes. Biochemical studies and high-throughput approaches validated the hierarchical composition of this FOXA1-nucleated machinery and revealed the depen...
ORGANISM(S): Homo sapiens (Human) 
2016-06-08 | PXD004271 | Pride
Human Lc-msms 
UnknownAggregate index of systemic inflammation as a novel prognostic biomarker in Chinese patients with acute decompensated heart failure: a population-based real-world study
Not available
S-EPMC12380547 | biostudies-literature
MetabolomicsHepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice
3,5,6-Trichloro-2-pyridinol (TCP) is a primary degradation product of chlorpyrifos and chlorpyrifos-methyl. TCP has longer half-life in soil and greater solubility in water than its parent compound, and cause wide contamination in environments. However, studies about the toxic effects of TCP are lim...
2017-05-05 | MTBLS275 | MetaboLights
MetabolomicsEvaluation of the toxic effects of municipal wastewater effluent on mice using omic approaches
Municipal wastewater effluents (MWWE) contain a lot of trace organic pollutants, which will be a threat to environmental health. However, little information is available for the mixed toxicity of MWWE on mammals. In the present study, male mice were exposed to MWWE for 90 days, and then, histopathol...
2018-10-11 | MTBLS48 | MetaboLights
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