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ProteomicsLysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus Radiodurans
D. radiodurans is distinguished by the most radioresistant organism identified to date. Lysine acetylation is a highly conserved post-translational modification that plays an essential role in the regulation of many cellular processes and may contribute to its extraordinary radioresistance. We integ...
ORGANISM(S): Deinococcus radiodurans R1 
2022-08-09 | PXD035309 | Pride
Deinococcus radiodurans  lysine acetylation  dna damage  posttranslational modification 
ProteomicsDiscovery and validation of glucose-sensitive peptides from human serum albumin as the candidate peptide biomarkers for diagnosis of type 2 diabetes mellitus
Glycation albumin(GA) has emerged as a biomarker for diagnosing prediabetes and diabetes, which is shorter than the "gold standard" reflection period of blood glucose detection. However, the GA response is the global glycation rate of albumin, individual amino acid residues might be sensitive indica...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038794 |
ProteomicsRadiation tolerance mechanism of Deinococcus radiodurans using lable-free proteomics
Even though these results have shown several key proteins played an import role in radiation tolerance mechanism of DR, they were lack of the deep protein coverage, global protein analysis as well as the dynamic changes of DR, which limits further understanding of biological changes in response to i...
ORGANISM(S): Deinococcus radiodurans 
2022-08-29 | PXD027969 | Pride
Deinococcus radiodurans  radiation  label-free quantitative proteomics 
UnknownDesign and synthesis of 2-phenyl-1<i>H</i>-benzo[<i>d</i>]imidazole derivatives as 17β-HSD10 inhibitors for the treatment of Alzheimer's disease.
Not available
S-EPMC11947984 | biostudies-literature
ProteomicsDifferential Proteomics of pprI-Knockout Deinococcus radiodurans: A Label-Free Quantitative Analysis
Deinococcus radiodurans, renowned for its exceptional resistance to radiation, provides a robust model for elucidating cellular stress responses and DNA repair mechanisms. The global regulator PprI plays a pivotal role in maintaining this resilience by coordinating DNA damage repair, antioxidant def...
ORGANISM(S): Deinococcus radiodurans 
2025-06-30 | PXD062500 | Pride
Radiation response metalloprotease  label-free quantitative proteomics  dna damage repair  antioxidant defense  metabolic regulation 
ProteomicsLarge-scale qualitative and quantitative research of dityrosine crosslinking omics in Escherichia coli
Excessive reactive oxygen species cause oxidative stress in cells. Two molecules of tyrosine can generate dityrosine, which is not only a product of natural posttranslational processes, but also a putative biomarker for protein oxidation. Few studies have investigated dityrosine crosslinking under e...
ORGANISM(S): Escherichia coli 
2023-05-10 | PXD039132 | Pride
Hydrogen peroxide Dityrosine crosslinking Label-free proteomics 
UnknownAn enzyme-responsive double-locked amonafide prodrug for the treatment of glioblastoma with minimal side effects.
Not available
S-EPMC11528907 | biostudies-literature
ProteomicsMulti-omics investigation of Rhodococcus sp. strain DN22
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a persistent nitramine explosive with long-lasting properties. Rhodococcus sp. strain DN22 has been discovered as one of the microorganisms capable of RDX degradation. Despite respectable studies on Rhodococcus sp. strain DN22, the proteins participat...
ORGANISM(S): Rhodococcus sp. DN22 
2024-05-22 | PXD044565 | Pride
Rdx biodegradation  rhodococcus sp. strain dn22  genome sequencing  proteomics  metabolomics 
ProteomicsStandard operating procedure combined with comprehensive quality control system to enable large-scale urinary proteomics across multiple LC-MS platforms for precision medicine
In this study, we carried out a comprehensive evaluation of multiple LC-MS platforms in urinary proteomics including 756 proteome measurements. A series of interrelated studies was designed to assess the intra- and inter-platform consistency and reproducibility. First, we optimized the method for u...
ORGANISM(S): Homo Sapiens Escherichia Coli Saccharomyces Cerevisiae 
2024-10-28 | PXD050291 |
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