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Angiotensin II (Ang II) mediated signaling plays a key role in the development of hypertension associated target organ damages. However, the gene expression changes regulated by Ang II in the early stage of acute cerebral, cardiac, renal, vascular injury remain unclear. we investigated Ang IIâ??medi...
ORGANISM(S): Mus musculus 
Atrial fibrillation (AF) is the most common form of arrhythmia observed in clinical cardiac diseases. Angiotensin II (Ang II) and elevation of blood pressure have been considered to be the main risk regulators of AF. However, the time series proteome profiling and the key signaling pathways involved...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD022238 | Pride
The clinical application of doxorubicin as a broad-spectrum anti-tumor antibiotic is limited greatly by its cardiotoxicity. Various mechanisms have been studied, but little is known about whether genes or pathways relevant with energy metabolism contributes to doxorubicin-induced cardiomyopathy or n...
ORGANISM(S): Mus musculus 
Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the classical heat shock response. However, the subcellular coordination of these stress responses remains poorly understood. In this study, we identify reversi...
ORGANISM(S): Homo Sapiens 
2026-01-23 | PXD073534 |
Using patient derived lung cancer organoids to predict clinical response and find theraputic mechanisms
ORGANISM(S): Homo Sapiens 
2022-09-26 | PXD037076 |
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