Zhao Ende E - OmicsDI

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Myeloid derived suppressor cells enhance stemness of cancer cells by inducing miRNA101 and suppressing the corepressor CtBP2

The work identifies an immune associated cellular, molecular and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. Primary ovarian cancer cells (5 x105) were co-cultured with freshly sorted ovarian cance...

ORGANISM(S): Homo sapiens

2013-08-23 | E-GEOD-50082 | biostudies-arrayexpress

Epigenetic silencing of Th1 chemokines shapes tumor immunity, immunotherapy and patient outcome [shEZH2]

To define the gene profile altered by EZH2 and H3K27me3 in response to IFNg, we performed several microarrays in primary ovarian cancer cells transfected with shEZH2 or treated with GSK126. We found that 155 and 124 genes were altered by shEZH2 and GSK126 treatment, respectively, and 20 genes were i...

ORGANISM(S): Homo sapiens

2015-08-11 | E-GEOD-71870 | biostudies-arrayexpress

Epigenetic silencing of Th1 chemokines shapes tumor immunity, immunotherapy and patient outcome [GSK126]

ORGANISM(S): Homo sapiens

2015-08-11 | E-GEOD-71869 | biostudies-arrayexpress

Genetic insights into resting heart rate and its role in cardiovascular disease.

Not available

S-EPMC10397318 | biostudies-literature

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Not available

S-EPMC6342931 | biostudies-literature

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.