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TranscriptomicsAtoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells
The morphogen and mitogen, Sonic Hedgehog, activates a Gli1-dependent transcription program that drives proliferation of granule neuron progenitors (GNPs) within the external germinal layer of the postnatally developing cerebellum. Medulloblastomas with mutations activating the Sonic Hedgehog signa...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-19684 | biostudies-arrayexpress
ProteomicsAdipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis
Adipose Energy Homeostasis is the important guarantee to maintain the body's energy balance. Recently, it is reported that, in the adipose cell, Kisspeptins play important role in cell proliferation, differentiation, lipid metabolism and some adipocytokine secretion, so Kisspeptins maybe the novel t...
ORGANISM(S): Mus Musculus 
PXD051630 |
ProteomicsDARTS-MS chemoproteomic profiling of ginkgolide J-associated protease-susceptibility candidate proteins in rat PASMC lysates
This dataset contains DIA-MS raw files and processed DIA-NN results from a DARTS-MS chemoproteomic experiment designed to identify ginkgolide J-associated protease-susceptibility candidate proteins in primary rat pulmonary artery smooth muscle cell (PASMC) lysates. The experiment included three grou...
ORGANISM(S): Rattus Norvegicus 
PXD078800 |
ProteomicsBCAT1 Confers Resistance to EGFR TKIs through α-KG-dependent Epigenetic Regulation of the Glycolysis Pathway in NSCLC
Epidermal growth factor receptor (EGFR) mutations are leading oncogenic drivers in non-small cell lung cancer (NSCLC). Many third-generation EGFR tyrosine kinase inhibitors (TKIs) have been developed to target EGFR T790M and activating mutations. Osimertinib (AZD9291) was the first approved drug and...
ORGANISM(S): Homo Sapiens 
PXD043776 |
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