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ProteomicsEarly urinary candidate biomarkers and clinical outcomes of intervention in a rat model of experimental autoimmune encephalomyelitis
In the present study, we used two-dimensional high-resolution mass spectrometry to investigate changes in the urinary proteome during the early stages of multiple sclerosis in EAE rat models. Urine samples were analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) before...
ORGANISM(S): Rattus Rattus 
2023-06-15 | PXD043037 |
ProteomicsInhibition of circulating glycocholic acid-regulated signaling potentiates immune checkpoint therapy in colorectal cancer
Serum bile acids (BAs) emerge as risk factors for cancer, but their roles in colorectal cancer (CRC) remain unclear. We show that glycocholic acid (GCA), a primary BA, is elevated in the serum of CRC patients. In a mouse CRC model, GCA promotes tumor programmed death-ligand 1 (PD-L1) expression in t...
ORGANISM(S): Mus <genus> 
2026-03-03 | PXD075127 |
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