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MetabolomicsResearch on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
UnknownBiological Potential and Mechanism of Prodigiosin from Serratia marcescens Subsp. lawsoniana in Human Choriocarcinoma and Prostate Cancer Cell Lines.
Not available
S-EPMC6274741 | biostudies-literature
ProteomicsHEK293T cells were transfected with Flag-tagged NLRP3 treated with or without nigericin (10 μM, 1 h).
In order to identificate NLRP3 acetylation, we utilized an acetylproteomic approach to identify the acetylation sites within NLRP3. We first reconstituted the NLRP3 inflammasome in HEK293T cells by co-transfected with plasmids encoding NLRP3, ASC, Caspase-1 and Pro-IL-1β, then stimulated the genetic...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-25 | PXD041763 | Pride
Hek293tcells， nlrp3 
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
MetabolomicsA Combined Proteomic and Metabolomic Strategy for Allergens Characterization in Natural and Fermented Brassica napus Bee Pollen

Bee pollen is consumed for its nutritional and pharmacological benefits, but it also contains hazardous allergens which has not been identified. Here, we identified 2 potential allergens, glutaredoxin and oleosin-B2, in Brassica napus (B. napus) bee pollen using mass spectrometr...

2022-03-23 | MTBLS3950 | MetaboLights
Transcriptomicsflagellar regulon studies
This study examined the genes under the control of FlhDC and sigmaF in E. coli. Keywords: wild-type, deletion and overexepression strains Under defined steady-state growth condition, we used two different genetic approaches to alter the modulator concentration in cells; (1) moderately expressing Fl...
ORGANISM(S): Escherichia coli 
2009-05-01 | E-GEOD-5818 | biostudies-arrayexpress
MetabolomicsGut microbiota-driven regulation of queen bee ovarian metabolism

With the global prevalence of Varroa mites, more and more beekeepers resort to confining the queen bee in a queen cage to control mite infestation or to breed superior and robust queen bees. However, the impact of such practices on the queen bee remains largely unknown. Therefore, we sub...

2023-09-11 | MTBLS7576 | MetaboLights
GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
ProteomicsA proteomic investigation of the dorsal muscle in Tibetan sheep
Firstly, the back muscle samples of Tibetan sheep of the same age were collected for subsequent proteomic analysis. The integrated and analyzed results aimed to identify proteins and pathways associated with meat quality and growth regulation in sheep, thereby providing a theoretical foundation for...
ORGANISM(S): Ovis Aries 
2024-07-26 | PXD054235 |
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