Sort   by:  
 Page size 
TranscriptomicsRAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors
Aberrant Shh signaling promotes tumor growth in diverse human cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the Shh pathway component Smoothened (Smo) show great therapeutic promise. However, the emergen...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-69359 | biostudies-arrayexpress
UnknownTBL1X and Flot2 form a positive feedback loop to promote metastasis in nasopharyngeal carcinoma.
Not available
S-EPMC8771836 | biostudies-literature
UnknownSmall Molecule Inhibitors of the PCSK9·LDLR Interaction.
Not available
S-EPMC6404525 | biostudies-literature
UnknownMutation detection in Chinese patients with familial hypercholesterolemia.
Not available
S-EPMC5153400 | biostudies-literature
GenomicsPI3K/AKT signaling regulates H3K4 methylation in breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-80594 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis reveals novel function of DDRGK1 in osteosarcoma
DDRGK1 is identified as a target of ufymaltion, while its function in tumor is still largely unknown and even controversial according to recent study. To invesgate the role of DDRGK1 in osteosarcoma, DDRGK1 gene was knockout in 143B cells by CRISPR/cas9, and recombinant DDRGK1 protein was added in t...
ORGANISM(S): Homo Sapiens 
PXD035473 |
GenomicsGenome-wide survey of YY1 targets in C2C12 cells by High-throughput sequencing
By applying ChIP-seq, we generated genome-wide maps of YY1 in skeletal myoblasts and myotubes. We found that YY1 binds to 1820 confident target with a large portion residing in the intergenic regions. In addition, YY1 was found to activate many loci, and there is no significant overlap between YY1 a...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-45875 | biostudies-arrayexpress
Genomicsena-DATASET-BGI-31-12-2014-03:23:33:590-567 - samples
Gastric Cancer (GC) is a highly heterogeneous disease. To identify potential clinically actionable therapeutic targets that may inform individualized treatment strategies, we performed whole-exome sequencing on 78 GCs of differing histologies and anatomic locations, as well as whole-genome sequencin...
EGAD00001001118 | EGA
GenomicsWGS and WES of 78 pairs Chinese gastric cancer
Gastric Cancer (GC) is a highly heterogeneous disease. To identify potential clinically actionable therapeutic targets that may inform individualized treatment strategies, we performed whole-exome sequencing on 78 GCs of differing histologies and anatomic locations, as well as whole-genome sequencin...
EGAS00001001056 | EGA
TranscriptomicsMessenger RNA expression after MK2206/DMSO treatment of T47D cells
We performed RNA-seq in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We show that a group of transcripts is differentailly expressed after AKT inhibition. Comparison of mRNA levels using RNA-seq after AKT inhibition vs vehicle
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-80591 | biostudies-arrayexpress
Sort   by:  
 Page size