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TranscriptomicsPersistence of seed-based activity following microRNA segmentation
microRNAs are M-bM-^HM-<22 nucleotide regulatory RNAs that are processed into duplexes from hairpin structures and incorporated into Argonaute proteins. We find that a nick in the middle of the guide strand of an miRNA sequence allows for seed-based targeting characteristic of miRNA activity. Insert...
ORGANISM(S): Homo sapiens 
2010-11-12 | E-GEOD-25224 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis on the Differences of Gene Expression in Longissimus Dorsi Muscle Tissue between 1-month and 24-month Chinese Red Steppes
In order to establish the correlation between biological processes and the mechanisms of gene expression controlling beef traits formation in bovine, microarray analysis was performed to capture the differences in gene expression related to beef traits profile in Longissimus Dorsi muscle tissue betw...
ORGANISM(S): Bos taurus 
2013-06-01 | E-GEOD-21782 | biostudies-arrayexpress
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Given that Aflatoxin B1 exposure drives 5% to 28% of global hepatocellular carcinoma cases, the critical paucity of effective interventions for Aflatoxin B1-induced liver injury represents an urgent need. Here, we discover that a cereal-derived polyph...

2026-08-13 | MTBLS13667 | MetaboLights
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Aflatoxin B1 (AFB1)-induced hepatic inflammation poses severe global health burdens with limited interventions. Here, we demonstrated that ferulic acid (FA), a cereal-derived polyphenol, alleviated AFB1 hepatotoxicity by remodeling gut microbiota and activating microbial tryptopha...

2026-08-14 | MTBLS12942 | MetaboLights
ProteomicsProteomic analysis of GM-CSF and M-CSF polarized bone marrow derived macrophages
Bone marrow cells were isolated, primed with M-CSF (M-BMDM) or GM-CSF (GM-BMDM) and cultured for 7 days. The proteomic difference between GM-BMDM and M-BMDM were analyzed to describe the phenotye and function of two types of macrophages.
ORGANISM(S): Mus Musculus 
PXD041180 |
ProteomicsThe protein mass spectrometry dataset for ovarian cancer research
This project provides a dataset for proteomic research on ovarian cancer based on mass spectrometry technology, including the raw MS/MS data of 396 samples from ovarian cancer patients and healthy controls. This data aims to provide important resources for discovering novel biomarkers of ovarian can...
ORGANISM(S): Homo Sapiens 
PXD075600 |
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