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GenomicsATRX tolerates activity-dependent histone H3 M-bM-^@M-^\methyl/phos switchingM-bM-^@M-^] to maintain repetitive element silencing in neurons
ATRX is a member of the SWI2/SNF2 family of chromatin remodeling proteins and primarily functions at heterochromatic loci via its recognition of M-bM-^@M-^XrepressiveM-bM-^@M-^Y histone modifications (e.g., H3K9me3). Despite significant roles for ATRX during normal neural development, as well as its...
ORGANISM(S): Mus musculus 
2015-01-02 | E-GEOD-64062 | biostudies-arrayexpress
GenomicsDNA double-strand breaks induced by high NaCl occur predominantly in gene deserts
High concentration of NaCl increases DNA breaks both in cell culture and in vivo. The breaks remain elevated as long as NaCl concentration remains high and are rapidly repaired when the concentration is lowered. Repair of the breaks after NaCl is reduced is accompanied by formation of foci containi...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-32882 | biostudies-arrayexpress
MetabolomicsCharacterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling
This study centered on detecting potentially anti-inflammatory active constituents in ethanolic extracts of Chinese Lonicera species by taking an UHPLC-HRMS-based metabolite profiling approach. Extracts from eight different Lonicera species were subjected to both UHPLC-HRMS analysis and to pharmacol...
2022-11-17 | MTBLS3112 | MetaboLights
ProteomicsMouse Neuroblastoma Cells Proteome by LC-MS/MS
N2a cells were transfected with pCAGGS vector or pCAGGS-RABV-M (expressing rabies virus matrix protein) for 36 hours, cells were lysed for SDS-PAGE. The area where the proteins were located in the SDS-PAGE was scooped and cut into small pieces of about 1 mm3; the decolorization solution (15 mM K3Fe(...
ORGANISM(S): Mus Musculus 
2023-08-09 | PXD044493 |
UnknownIdentification of consistent post-translational regulatory triplets related to oncogenic and tumour suppressive modulators in childhood acute lymphoblastic leukemia.
Not available
S-EPMC8286060 | biostudies-literature
GenomicsGenome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
We developed a method, ChIP-sequencing (ChIP-seq), combining chromatin immunoprecipitation (ChIP) and massively parallel sequencing to identify mammalian DNA sequences bound by transcription factors in vivo. We used ChIP-seq to map STAT1 targets in interferon stimulated and unstimulated human HeLa S...
ORGANISM(S): Homo sapiens 
2009-03-23 | E-GEOD-15353 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the whole retina of rat intravitreally injected with aldosterone
The mineralocorticoid receptor is expressed in the rat and human retina. We previously showed that intravitreal injection of aldosterone in rat eyes induced retinal œdème and choroidal vasodilation and permeability through regulation of ion/water channels (Zhao et al. Faseb J, 2009; Zhao et al. J Cl...
ORGANISM(S): Rattus norvegicus 
2018-11-30 | E-MTAB-7438 | biostudies-arrayexpress
UnknownEffects of Sprint Interval Training on Brain Fatigue Resistance in Competitive Skateboarders: Evidence from EEG, HRV, and VAS Measures.
Not available
S-EPMC12843024 | biostudies-literature
GenomicsThe dynamics of DNA methylation fidelity during mouse embryonic stem cell renewal and differentiation
Purpose: we aimed to gain a genome-wide view of the dynamics in DNA methylation inheritance and define the factors associated with methylation fidelity. Methods: Using mouse embryonic stem cell (ES-E14TG2a) in both undifferentiated and differentiated states as a model system, we exploited the hairpi...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-48229 | biostudies-arrayexpress
MetabolomicsTranscriptomic and Metabolomics Profiling of Phage–Host Interactions between Phage PaP1 and Pseudomonas aeruginosa
The basic biology of bacteriophage–host interactions has attracted increasing attention due to a renewed interest in the therapeutic potential of bacteriophages. In addition, knowledge of the host pathways inhibited by phage may provide clues to novel drug targets. However, the effect of phage on ba...
2018-05-03 | MTBLS431 | MetaboLights
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