Sort   by:  
 Page size 
ProteomicsFTO inhibition attenuates obstruction-induced kidney fibrosis by downregulating ferroptosis activator ACSL4 and profibrotic factor TGFBI
Analysis by LC-MS/MS shotgun proteomics was performed on lysates from the following samples: 1) Control HK2 cells generated using control CRISPR/CAS9 system and scrambled guide RNA (sgRNAGCACTCACATCGCTACATCA) 2) HK2 cells with FTO knockout using CRISPR/Cas9 system and target 2 guide RNA (sgCCTACAAGT...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD051362 | Pride
Hk2 Ferroptosis Kidney fibrosis Fto 
ProteomicsProteomic analysis of LNCaP wildtype (WT) and LNCaP OR51E2-knock out xenograft mouse tumor tissue
Quantitative proteomic analysis of tumor tissue lysates from wildtype LNCaP (WT) and LNCaP OR51E2-/- (KO) xenografts in male CIEA NOG mice.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-03-26 | PXD055974 | Pride
Or51e2  prostate cancer  stat3  xenograft. 
UnknownFunctional characterization of CgCTR2, a putative vacuole copper transporter that is involved in germination and pathogenicity in Colletotrichum gloeosporioides.
Not available
S-EPMC2446676 | biostudies-literature
UnknownHigher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.
Not available
S-EPMC4910529 | biostudies-literature
UnknownMutations in POMGNT1 cause non-syndromic retinitis pigmentosa.
Not available
S-EPMC4805308 | biostudies-literature
TranscriptomicsMicroRNA-520c-3p targets eIF4GII and acts as a tumor suppressor in diffuse large B cell lymphoma
Deregulation of the translational machinery is emerging as a critical contributor to lymphomagenesis. Various miRNA alterations have been identified in lymphoma, but their role in disrupting the cap-dependent translation regulation complex remains poorly understood. Here, we demonstrate the translat...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-40489 | biostudies-arrayexpress
UnknownDiscovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Not available
S-EPMC10861881 | biostudies-literature
GenomicsNational Cancer Institute (NCI) TARGET: Therapeutically Applicable Research to Generate Effective Treatments

The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative seeks to accelerate research in novel marker and drug development, along with understanding the molecular basis of pediatric malignancy, through identification of genomic changes associated with the follo...

phs000218.v5.p1 | EGA
UnknownRLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Not available
S-EPMC10481131 | biostudies-literature
GenomicsAcquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

We performed genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult patients with de novo AML using the Affymetrix Genome-Wide Human SNP array 6.0 containing 1.85 million features. Acquired copy number alterations (CNA) were confirmed using an independent, hig...

phs000201.v1.p1 | EGA
Sort   by:  
 Page size