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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
UnknownPhotoactivation mechanism of a carotenoid-based photoreceptor.
Not available
S-EPMC5474822 | biostudies-literature
UnknownThe interplay between chromophore and protein determines the extended excited state dynamics in a single-domain phytochrome.
Not available
S-EPMC7368379 | biostudies-literature
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
UnknownStructure and mechanism of the phycobiliprotein lyase CpcT.
Not available
S-EPMC4175310 | biostudies-literature
ProteomicsPhysiological and proteomic analysis responsive mechanisms for salt stress in oat
Oat is considered as a moderately salt-tolerant crop that can be used to improve saline and alkaline soils. Previous studies have focused on short-term salt stress exposure, and the molecular mechanisms of salt tolerance in oat have not yet been elucidated. In this study, the salt-tolerant oat varie...
ORGANISM(S): Oryza Sativa 
PXD034203 |
ProteomicsProteomic Profiling and Biomarker Discovery for Predicting Response to PD-1 Inhibitor Immunotherapy in Gastric Cancer Patients
Revolutionizing cancer treatment, immune checkpoint inhibitors (ICIs) have nonetheless encountered a challenge: a substantial portion of gastric cancer (GC) patients don’t respond to this therapy. This pressing issue necessitates a deeper understanding of the resistance mechanisms against ICIs and t...
ORGANISM(S): Homo Sapiens 
2024-02-29 | PXD050228 |
ProteomicsProteomic and clinical biomarkers for acute mountain sickness diagnosis, prognosis, protection, and pathogenesis in a longitudinal cohort
We redefined AMS by using the combination of Olink’s antibody-based proximity extension assay and the multiple reaction monitoring mass spectrometry proteome with 106 paired plasma samples of Chinese Han, 22 AMS-related phenotypes, and 65 clinical indexes. We revealed a systematic proteomic and clin...
ORGANISM(S): Homo Sapiens 
PXD029063 |
ProteomicsLC-MS/MS-based metabolomics and proteomics reveal the intervention of Kangnian Decoction on the postoperative intestinal adhesion of rats
This study aims to explore the therapeutic effects of KN decoction in a PIA rat model, as well as its potential mechanisms via metabolomics and proteomics analyses.
ORGANISM(S): Rattus Norvegicus 
PXD055723 |
ProteomicsPan-analysis of Single Amino-acid Polymorphism
Uncovering dark mass in population proteomics: Pan-analysis of Single Amino-acid Polymorphism (Pan-SAP) revealed quantitative relevance with cognition and aging
ORGANISM(S): Homo Sapiens 
2024-12-31 | PXD059327 |
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