Sort   by:  
 Page size 
UnknownEffects of paired associative magnetic stimulation between nerve root and cortex on motor function of lower limbs after spinal cord injury: study protocol for a randomized controlled trial.
Classic paired associative stimulation can improve synaptic plasticity, as demonstrated by animal experiments and human clinical trials in spinal cord injury patients. Paired associative magnetic stimulation (dual-target peripheral and central magnetic stimulation) has been shown to promote neurolog...
S-EPMC9120678 | biostudies-literature
UnknownThe Kickstart Walk Assist System for improving balance and walking function in stroke survivors: a feasibility study.

Background

Compared with traditional physical therapy for stroke patients, lower extremity exoskeletons can provide patients with greater endurance and more repeatable and controllable training, which can reduce the therapeutic burden of the therapist. However, most exoskeletons are expensiv...
S-EPMC7905648 | biostudies-literature
UnknownSingle-cell mapping reveals age-related alterations in periosteal progenitor cells and immune microenvironment.
Aging profoundly impacts bone homeostasis and regeneration, yet the cellular and molecular mechanisms underlying periosteal aging remain poorly understood. Using single-cell RNA sequencing, we profiled the periosteum of 3-, 9-, and 18-month-old mice, which revealed age-related shifts in progenitor, ...
S-EPMC12623539 | biostudies-literature
UnknownSympathetic nerve inhibition enhances calvarial bone repair via senescent macrophage-induced osteogenesis and angiogenesis.
Bone regeneration is a tightly coordinated process involving multiple cellular and molecular components, with emerging evidence highlighting the pivotal role of the nervous system, especially the sympathetic nervous system, in modulating skeletal repair. However, the mechanistic details of neuro-ske...
S-EPMC12728170 | biostudies-literature
UnknownFinding the best predictive model for hypertensive depression in older adults based on machine learning and metabolomics research.

Objective

Depression is a common comorbidity in hypertensive older adults, yet depression is more difficult to diagnose correctly. Our goal is to find predictive models of depression in hypertensive patients using a combination of various machine learning (ML) methods and metabolomics.

Me...

S-EPMC11236531 | biostudies-literature
UnknownHaspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells.
Many different types of stem cells utilize asymmetric cell division (ACD) to produce two daughter cells with distinct fates. Haspin-catalyzed phosphorylation of histone H3 at Thr3 (H3T3ph) plays important roles during mitosis, including ACD in stem cells. However, whether and how Haspin functions in...
S-EPMC10447528 | biostudies-literature
UnknownPGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis.
Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of ...
S-EPMC8904489 | biostudies-literature
UnknownSingle-cell RNA Seq reveals cellular landscape-specific characteristics and potential etiologies for adolescent idiopathic scoliosis.

Backgrounds

Abnormal vertebral growth and development have been found in adolescent idiopathic scoliosis (AIS) patients, and the proliferation and differentiation of bone development-related cells play important roles in its pathogenesis. However, a comprehensive single-cell-level differenti...
S-EPMC8717101 | biostudies-literature
UnknownThe Frequency and Associated Factors of Asymmetrical Prominent Veins: A Predictor of Unfavorable Outcomes in Patients with Acute Ischemic Stroke.

Objectives

The present study is aimed at investigating the frequency and associated factors of asymmetrical prominent veins (APV) in patients with acute ischemic stroke (AIS).

Methods

Consecutive patients with AIS admitted to the Comprehensive Stroke Center of Shanghai Fourth People's...
S-EPMC8463180 | biostudies-literature
UnknownModulated effectiveness of rehabilitation motivation by reward strategies combined with tDCS in stroke: study protocol for a randomized controlled trial.

Background

Stroke survivors often exhibit low motivation for rehabilitation, hindering their ability to effectively complete rehabilitation training task effectively and participate in daily activities actively. Reward strategies have been identified as an effective method for boosting rehab...
S-EPMC10310965 | biostudies-literature
Sort   by:  
 Page size