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ProteomicsThe Glomerulus Multi-Omics Analysis Provides Deeper Insights into Diabetic Nephropathy
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD), however, the detail mechanisms remain unclear. Here, we integrated the transcriptomics and proteomics profiles of glomeruli isolated from 50 biopsy-proven DN patients and 25 controls to explore the new discoveries unde...
ORGANISM(S): Homo Sapiens 
2023-03-06 | PXD040617 |
ProteomicsProteome of uterine cavity fluid in female rattus
The injection with GnIH/saline through the lateral ventricle. At 6 h after injection, the protein components of rats in the experimental and control groups were analyzed using Liquid Chromatography (LC)-Mass Spectrometry (MS)/MS.
ORGANISM(S): Rattus Rattus 
2022-10-31 | PXD037826 |
ProteomicsLongitudinal CSF proteomic profiling in pediatric acute necrotizing encephalopathy
Background Acute necrotizing encephalopathy (ANE) is characterized by fulminant neuroinflammation and highly heterogeneous responses to immunotherapy in children. The molecular drivers of this heterogeneity remain unclear, and early biomarkers that can reliably predict therapeutic response and clini...
ORGANISM(S): Homo Sapiens 
2025-11-28 | PXD071345 |
ProteomicsProteomics Characterization of COVID-19 lung tissues
The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underly...
ORGANISM(S): Homo Sapiens 
2020-03-19 | PXD018094 |
ProteomicsArtificial intelligence defines protein-based classification of thyroid nodules
We applied PCT-DIA on a total of 1161 nodules from 1133 patients using either tissue cores (1 mm diameter; 0.5–1 mm depth) punched from regions of interest marked on retrospective FFPE tissue blocks or prospective cytology specimens from FNA aspirates. The samples comprise (i) a discovery set of FFP...
ORGANISM(S): Homo Sapiens 
2022-09-07 | PXD036554 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2020-07-30 | PXD020653 |
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