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ProteomicsDiscovering new peripheral plasma biomarkers to identify cognitive decline in type 2 diabetes
Type 2 diabetes mellitus (T2DM) is an independent risk factor of Alzheimer's disease (AD), thus, identifying who among the increasing T2DM populations may develop into AD is important for early intervention. By using TMT-labeling coupled high-throughput mass spectrometry, we conducted a comprehensiv...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027870 | Pride
Type 2 diabetes Mild cognitive impairment Proteomics Cip2a Alzheimer's disease Diagnostic biomarkers 
ProteomicsSynechocystis spatial proteome LC-MS/MS
We treated a unicellular photosynthetic model cyanobacterium, Synechocystis sp. PCC 6803, with five different types of abiotic stresses including nitrogen starvation, iron deficiency, cold, heat, and darkness, and systematically identified proteins showing stress-induced differential expression and/...
ORGANISM(S): Synechocystis sp. PCC 6803 
2023-03-20 | PXD035771 | Pride
Synechocystis total membrane soluble lc-ms/ms 
Proteomicsproteomic response of S. aureus with entrectinib treatment
S. aureus isolate was inoculated and cultured to exponential growth phase (OD600 at 0.5) in TSB and divided into two groups, the control group and the drug treated group. Entrectinib was added to the drug treated group until a final concentration of 1/2× MIC reached, and DMSO added in the control gr...
ORGANISM(S): Staphylococcus Aureus 
2022-11-23 | PXD038342 |
ProteomicsTargeting mitochondria-inflammation circuit by β-hydroxybutyrate mitigates heart failure with preserved ejection fraction
Rationale: Over 50% of heart failure patients have preserved, rather than reduced ejection fraction (HFpEF vs. HFrEF). Complexity of its pathophysiology and the lack of animal models hamper the development of effective therapy for HFpEF. Objective: This study was designed to investigate the metabol...
ORGANISM(S): Mus Musculus 
2021-10-22 | PXD021957 |
ProteomicsRisk stratification of thyroid papillary cancer based on proteomics and machine learning
Papillary thyroid cancer (PTC) is the most common type of thyroid carcinoma accounting for 85%. Most PTCs have a low risk of recurrence and metastasizing and not all low-risk PTCs need immediate surgery. However, cases are often recognized as low-risk only after surgery. Our study aimed to find a pr...
ORGANISM(S): Homo Sapiens 
2024-03-13 | PXD050577 |
ProteomicsMass spectrometry-based protein interactome and phosphoproteomics data upon NRDE2 overexpression
The HEK293T cells transiently expressing Flag-tagged empty vector or Flag-NRDE2-WT were lysed in NETN buffer (10 mM Tris-HCl [pH 8.0], 100 mM NaCl, 1 mM EDTA, and 0.5% NP-40) and immunoprecipitated with anti-Flag M2 agarose (M8823; Sigma-Aldrich, MO, USA). After washing four times with the high stri...
ORGANISM(S): Homo Sapiens 
2024-03-31 | PXD051117 |
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