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ProteomicsCIP2A interactome in human Th17 Cells
CIP2A immunoprecipitation (IP) was carried out with two specific anti CIP2A antibodies that recognize distinct regions of CIP2A protein and respective Immunoglobulin G (IgG) were used in control IPs as a negative control. The digested samples were analyzed by LC-MS/MS to identify CIP2A protein netwo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD008983 | Pride
Th17 cells Cord blood Cip2a Interactome Lc-ms/ms 
ProteomicsLabel-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling
Label-free quantification is a powerful method for studying cellular protein phosphorylation dynamics. However, whether current data normalization methods achieve sufficient accuracy has not been examined systematically. Here, we demonstrate that a large uni-directional shift in the phosphopeptide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080775 | MassIVE
ProteomicsCIP2A negatively regulates Th17 differentiation
Interleukin 17 (IL-17) producing T helper 17 (Th17) cells are critical drivers of pathogenesis in a variety of autoimmune and inflammatory diseases. Strategies to mitigate excessive Th17 response thus remain an attractive target for immunotherapies. Here we report that Cancerous Inhibitor of Protein...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010612 | Pride
Th17 cell differentiation Stat3 phosphorylation 
TranscriptomicsTargeting c-MYC by antagonizing PP2A inhibitors in breast cancer
Inhibition of SET by siRNA or SET antagonist and CIP2A by siRNA can downregulate c-MYC and c-MYC target genes. Cells were treated with a SET antagonist (1μMOP449) for 12 hours, or siRNA for 48 hours.
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-58008 | biostudies-arrayexpress
ProteomicsStructural mechanism for inhibition of PP2A-B56 and oncogenicity by CIP2A
Abstract The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56 is a human tumor suppressor. However, the molecular mechanisms inhibiting PP2A-B56in cancer are poorly understood. Here, we report molecular level details and structural mechanism of PP2A-B56inhibition by an oncoprotein CIP2A. Upon di...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD030297 | Pride
Ap-ms Protein phosphatase Mouse Oncogene Interactome 
ProteomicsThe CIP2A-TOPBP1 axis orchestrates mitotic DNA repair
DNA double-strand breaks (DSBs) accumulate in mitosis in response to DNA replication stress or deficiency in breast cancer susceptibility type 1 and 2 (BRCA1/2). This is a critical threat to genome stability as the classical DSB repair pathways non-homologous end joining (NHEJ) and homologous recomb...
ORGANISM(S): Homo sapiens (Human) 
2025-09-19 | PXD068371 | Pride
Cip2a-topbp1 
TranscriptomicsscRNA-seq of lymph node of mice where Cip2a locus has been disrupted and wild-type control mice at the peak of Experimental Autoimmune Encephalomyelis
We induced EAE in mice carrying a gene-trap disruption of Cip2a (hereafter referred to as knockout [KO] mice) and wild-type (WT) control C57BL/6J male and female mice, aged 8-12 weeks. We performed scRNA-seq analysis of lymph node cells from five WT and five KO mice at the peak of EAE. The goal was ...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-17644 | biostudies-arrayexpress
ProteomicsLabel-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling
Label-free quantification is a powerful method for studying cellular protein phosphorylation dynamics. However, whether current data normalization methods achieve sufficient accuracy has not been examined systematically. Here, we demonstrate that a large uni-directional shift in the phosphopeptide ...
ORGANISM(S): Homo sapiens (Human) 
2015-08-24 | PXD001374 | Pride
Mascot Phosphoproteomics Cip2a Hela Okadaic acid Ras Simspectrast Lc-ms/ms 
GenomicsCancerous inhibitor of PP2A (CIP2A) Constrains Th17 Differentiation by Modulating STAT3 Signaling
Cancerous inhibitor of PP2A (CIP2A) Constrains Th17 Differentiation by Modulating STAT3 Signaling
PRJNA484395 | ENA
GenomicsRNA-sequencing of control and DMBA-treated WT and Cip2a-/- mouse mammary glands
RNA-sequencing of control and DMBA-treated WT and Cip2a-/- mouse mammary glands
PRJNA725446 | ENA
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