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ProteomicsThe CIP2A-TOPBP1 axis orchestrates mitotic DNA repair
DNA double-strand breaks (DSBs) accumulate in mitosis in response to DNA replication stress or deficiency in breast cancer susceptibility type 1 and 2 (BRCA1/2). This is a critical threat to genome stability as the classical DSB repair pathways non-homologous end joining (NHEJ) and homologous recomb...
ORGANISM(S): Homo sapiens (Human) 
2025-09-19 | PXD068371 | Pride
Cip2a-topbp1 
ProteomicsCIP2A-TOPBP1 Interaction in Human Mitotic Cells
We investigate the implications of DNA double strand breaks in the human genome, regarding the progression and treatment of various cancer types. During mitosis, the canonical DNA repair mechanisms are suspended while broken chromosomes get temporarily stabilized through so-called adapter proteins. ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD034100 | Pride
Uzh Human Cancer Pull-down Mitosis Lc-ms/ms 293t Q-exactive Usz Topbp1 Cip2a Uplc Fgcz Nanoacquity 
UnknownThe CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
Not available
S-EPMC9288427 | biostudies-literature
UnknownCIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.
Not available
S-EPMC8373817 | biostudies-literature
UnknownThe CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ.
Not available
S-EPMC12661054 | biostudies-literature
ProteomicsCIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to replication stress-induced DNA lesions to maintain genome integrity
Perturbed DNA replication can result in genomic regions that remain incompletely replicated at the point that cells enter mitosis. Transmission of replication-mediated DNA lesions into mitosis may prevent proper chromosomes segregation, and cells therefore require mechanisms to resolve these lesions...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD059881 | Pride
None 
UnknownCIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions.
Not available
S-EPMC12765896 | biostudies-literature
Genomics
CIP2A is a prime synthetic lethal target for BRCA-mutated cancers
PRJNA753451 | ENA
UnknownMitotic tethering enables inheritance of shattered micronuclear chromosomes.
Not available
S-EPMC10424572 | biostudies-literature
UnknownOncogene Silencing via ecDNA Micronucleation.
Not available
S-EPMC12047879 | biostudies-literature
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