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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsEgr2-dependent expression in T cell anergy
T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46242 | biostudies-arrayexpress
TranscriptomicsConserved non-coding sequence 2 (CNS2) of the Foxp3 genomic locus is essential for the function and stability of regulatory T cells during their activation
Regulatory T (Treg) cells play an indispensable role in immune homeostasis. The development and function of Tregs are dependent on transcriptional factor Foxp3, but how constant expression of Foxp3 is maintained in Tregs is not clear. Here we show that ablation of the conserved non-coding DNA seque...
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-57272 | biostudies-arrayexpress
TranscriptomicsRole of EGR2 transcription factor in T cell anergy
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46243 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in tumor
Single-cell RNA-seq data for Trex1 WT and KO mice from the tumor. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16526 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in heart
Single-cell RNA-seq data for Trex1 WT and KO mice from the heart. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16525 | biostudies-arrayexpress
TranscriptomicsExpression data from yeast wild type (WT) and sod1M-NM-^T strains after treatment with hydrogen peroxide (H2O2)
An important cellular defense mechanism against oxidative stress is the induction of genes involved in ROS resistance and DNA damage repair. Under normal conditions, Sod1 is localized mainly in the cytosol. However, we found that Sod1 translocates into the nucleus after oxidative stress. To address ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-18 | E-GEOD-55081 | biostudies-arrayexpress
UnknownChimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma.
Not available
S-EPMC4646711 | biostudies-literature
TranscriptomicsNovel Immunotherapy-Induced Tertiary Lymphoid Aggregates Accumulate as Intratumoral Nodal Structures of Immune Regulation in Pancreatic Cancer
Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-52171 | biostudies-arrayexpress
UnknownCharacterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transporting Polypeptide (OATP) 1B1 c.521 T>C Nonsynonymous Single-Nucleotide Polymorphism.
Not available
S-EPMC8456979 | biostudies-literature
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