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ProteomicsKidney transcriptomic and proteomic analyses provide new insight into the pathogenesis of IgA nephropathy in mice
Background:Immunoglobulin A nephropathy (IgAN) is a common clinically refractory disease, and its pathogenesis remains unclear. Studying the pathogenesis of IgA nephropathy is of great significance for the clinical treatment of IgA nephropathy. Methods:The IgAN mouse model was established through or...
ORGANISM(S): Mus Musculus 
2024-08-15 | PXD054916 |
ProteomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity
RNA polymerase II (Pol II) subunits are thought to be involved in various transcription-associated processes, but it is unclear whether they play different regulatory roles in modulating gene expression. Here, we performed nascent and mature transcript sequencing after the acute degradation of 12 ma...
ORGANISM(S): Mus <genus> 
2022-08-09 | PXD035866 |
ProteomicsLarge-scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis
Neurosyphilis (NS) is a central nervous system infection caused by Treponema pallidum. NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as “the great imitator”, NS can be easily overlooked or misdiagnosed due to the absence of standard d...
ORGANISM(S): Homo Sapiens 
2024-02-16 | PXD033034 |
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