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The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
Most mammalian genes display alternative cleavage and polyadenylation (APA). Previous studies have indicated preferential expression of APA isoforms with short 3’UTRs in testes. Here we show widespread shortening of 3’UTR by APA during the first wave of spermatogenesis in mouse, with 3’UTRs be...
ORGANISM(S): Mus musculus 
The human liver plays a vital role in meeting the body's metabolic needs and maintaining homeostasis. To address the molecular mechanisms of liver function, we integrated multiple gene expression datasets from microarray, MPSS, SAGE and EST platforms to generate a transcriptome atlas of the normal h...
ORGANISM(S): Homo sapiens 
Failed clearance of apoptotic cells drives pathogen persistence, tissue damage, and damage associated molecular patterns accumulation, fueling immune remodeling. Despite its pathophysiological significance, the precise immunometabolic reprogramming underlying impaired phagocytic signaling in macroph...
ORGANISM(S): Homo Sapiens 
2025-10-14 | PXD069433 |
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