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MetabolomicsUnknown Metabolite Annotation in Mouse Aging using Ion Mobility Collision Cross-Section Atlas (AllCCS)

The metabolome includes not just known but also unknown metabolites; however, metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility – mass spectrometry (IM-MS) has emerged as a promising technology by providing multi-dimensional characterizations of metabolites. He...

2020-07-28 | MTBLS1622 | MetaboLights
MetabolomicsKnown Metabolite Annotation in Different Biological Samples using Ion Mobility Collision Cross-Section Atlas (AllCCS)

The metabolome includes not just known but also unknown metabolites; however, metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility – mass spectrometry (IM-MS) has emerged as a promising technology by providing multi-dimensional characterizations of metabolites. He...

2020-07-28 | MTBLS1693 | MetaboLights
MetabolomicsIon mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain
Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging brain and aging-dependent disorders such as neurodegenerative diseases. There is an unmet demand to comprehensively profile sterol lipids spatially and temporally in different brain regions during aging. Here...
2021-05-24 | MTBLS2457 | MetaboLights
ProteomicsProteomic data of Conogethes punctiferalis infected with Beauveria bassiana
Comparative iTRAQ-based quantitative proteomic analysis of Conogethes punctiferalis infected with Beauveria bassiana at 36 h
ORGANISM(S): Conogethes Punctiferalis 
2025-05-14 | PXD063941 |
UnknownNon-invasive high-frequency oscillatory ventilation versus nasal continuous positive airway pressure in extremely preterm infants with respiratory distress syndrome: study protocol for a multicentre randomised controlled, superiority trial.
Not available
S-EPMC9990689 | biostudies-literature
ProteomicsIntegrating SWATH-MS Proteomics and Transcriptome Analysis Identifies Three DEGs as Biomarkers for Proliferative Diabetic Retinopathy Running heading-Three Biomarkers for PDR
Although management of risk factors, including hyperglycemia, hyperlipidemia, and hypertension, have been shown to ameliorate diabetes-induced vision loss, effective noninvasive medical therapies for the prevention of PDR remain an unmet clinical need. We intended to find differentially expressed pr...
ORGANISM(S): Homo Sapiens 
2021-09-09 | PXD028227 |
ProteomicsCOVID-19 increases extracorporeal coagulation during hemodialysis through upregulation of vWF/FBNL5 signaling
Introduction: COVID-19 has been shown to increase the risk of extracorporeal coagulation during hemodialysis in patients, but the mechanism is unclear. This study aims to investigate the effect and mechanism of COVID-19 on the risk of extracorporeal coagulation during hemodialysis. Methods: A retro...
ORGANISM(S): Homo Sapiens 
2023-08-03 | PXD044377 |
ProteomicsThe Analysis of Plasma Metabolome and Lipidome of Patients with COVID-19
The ongoing outbreak of novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization. This disease is marked by its rapid progression from mild to severe conditions, particularly in the absence of adequate medical care. And the mortality rate o...
ORGANISM(S): Homo Sapiens 
2020-03-31 | PXD018307 |
ProteomicsTargeting Histone Modification Crosstalk as a Therapeutic Strategy for EZH2-aberrant Solid Tumors
Mutations or aberrant upregulation of the histone methyltransferase EZH2 occur frequently in human cancers yet EZH2-targeted therapies have only shown very limited clinical benefits in hematological malignancies. We report here that upon EZH2 inhibition, MLL1 interacts with p300/CBP complex that dir...
ORGANISM(S): Homo Sapiens 
2018-09-10 | PXD010842 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2020-07-30 | PXD020653 |
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