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GenomicsDistinct roles of DNMT1-dependent and –independent methylation patterns in the genome of mouse ES cells
We generated base-resolution DNA methylomes of a series of DNMT knockout (KO) ES cells with improved coverage at highly repetitive elements. We find that DNMT1- and DNMT3a/3b-dependent activities actually work complementarily and simultaneously to establish symmetric CG methylation and CHH (H=A, T o...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-61457 | biostudies-arrayexpress
ProteomicsNuclear HMGB1 is critical for CD8 T cell IFN-g production and anti-tumor immunity
HMGB1 has been extensively studied as a DAMP, with secreted cytokine function. However, its regulation on T cells, especially the function in the nucleus, has not been elucidated. Here, we extracted the total protein of CD8 T cells and enriched the proteins bound to HMGB1 through IP experiment. We...
ORGANISM(S): Mus Musculus 
2024-03-15 | PXD050639 |
TranscriptomicsExpression of microRNAs in rat kidney treated with a carcinogenic dose of Aristolochic Acid
Aristolochic Acid (AA), a natural component of Aristolochia plants found in a variety of herbal remedies and health supplements, is classified as a group 1 carcinogen by the International Agency for Research on Cancer. In order to search for miRNA regulation in AA-induced carcinogenesis, we treated ...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-54338 | biostudies-arrayexpress
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