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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
GenomicsGenome-wide mapping of Myc binding site (K562)
Proto-oncogene c-myc encodes a bHLH leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Myc can dimerize with other factors like Max, Mad, Mnt and Miz and can influence transcription of genes. The c-myc oncogene contributes to the genesis of a ...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-19547 | biostudies-arrayexpress
TranscriptomicsPromoter capture Hi-C of human airway smooth muscle cells
To identify distal chromatin contacts between promoters and their putative regulatory elements in human airway smooth muscle cells (ASMC), we performed Hi-C with a capture step to enrich the library for contacts involving promoters. Promoter capture Hi-C was performed according to PMID: 29988018 The...
ORGANISM(S): Homo sapiens 
2025-03-11 | E-MTAB-14295 | biostudies-arrayexpress
Proteomicsβ-Hydroxybutyrylation in Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM) is characterized by metabolic remodeling and energetic stress independent of coronary artery disease. Increased reliance on fatty acid and ketone body metabolism has been observed in DCM, but the regulatory mechanisms linking altered substrate utilization to myocardial ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD066713 | Pride
Diabetic cardiomyopathy  β-hydroxybutyrylation (kbhb)  metabolic remodeling  ketone body metabolism  mitochondrial regulation 
ProteomicsComparative analysis of maca (Lepidium meyenii) proteome profiles reveals insights into response mechanisms of herbal plants to high-temperature stress
High-temperature stress (HTS) is one of the main environmental stresses that limit plant growth and crop production in agricultural systems. Maca (Lepidium meyenii) is an important high-altitude herbaceous plant adapted to a wide range of environmental stimuli such as cold, strong wind and UV-B expo...
ORGANISM(S): Lepidium meyenii 
2020-08-25 | PXD021042 | Pride
High-temperature stress Stress response Tandem mass tag Molecular mechanism Maca 
ProteomicsBlockade of mitochondrial components release by exosome pathway promotes the pathogenesis of Fuchs endothelial corneal dystrophy
Fuchs endothelial corneal dystrophy (FECD) is the leading indication of corneal transplantation worldwide and the focus of pathogenesis has been on the corneal endothelium. Instead of cellular analysis, we aimed to identify the protein changes of aqueous humor (AH) in patients with FECD and investig...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD065309 | Pride
Fuchs endothelial corneal dystrophy  proteomics  aqueous humor  corneal endothelium  mitochondrial quality control 
ProteomicsThe distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana resolve the Central Dogma’s information flow
A label-free proteomics dataset from our investigation of the interplay of constitutive gene-body CpG methylation (gbM), tRNA abundance and codon composition on mRNA and protein expression, in the plant Arabidopsis thaliana. We performed genomic profiling in rosette leaves of two Arabidopsis accessi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-07-31 | PXD058342 | Pride
Dia Arabidopsis Leaf Diapasef Can-0 Col-0 
UnknownMyristoylation alone is sufficient for PKA catalytic subunits to associate with the plasma membrane to regulate neuronal functions.
Not available
S-EPMC8053988 | biostudies-literature
GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of rat dorsal root ganglions treated with paclitaxel against untreated controls
L4-L5 segment dorsal root ganglion (DRG) samples from controls and the paclitaxel-induced peripheral neuropathy (PIPN) rats were collected at day 14 after the initiation of paclitaxel treatment. Paclitaxel and vehicle were administered intraperitoneally at 2 mg/kg for four consecutive days at a fina...
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13430 | biostudies-arrayexpress
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