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UnknownMitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies.
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S-EPMC10216385 | biostudies-literature
GenomicsINO80 governs super-enhancer-mediated oncogenic transcription and tumor growth in melanoma [ChIP-seq_MiSeq]
Super-enhancers (SEs) are large genomic regions with high density of enhancer marks. In cancer, SEs are found near oncogenes and dictate cancer gene expression. However, how oncogenic SEs are regulated remains poorly understood. Here, we show that INO80, a chromatin remodeling complex, is required f...
ORGANISM(S): Homo sapiens 
2016-07-07 | E-GEOD-82331 | biostudies-arrayexpress
GenomicsINO80 governs super-enhancer-mediated oncogenic transcription and tumor growth in melanoma [ChIP-seq_NextSeq]
Super-enhancers (SEs) are large genomic regions with high density of enhancer marks. In cancer, SEs are found near oncogenes and dictate cancer gene expression. However, how oncogenic SEs are regulated remains poorly understood. Here, we show that INO80, a chromatin remodeling complex, is required f...
ORGANISM(S): Homo sapiens 
2016-07-07 | E-GEOD-82332 | biostudies-arrayexpress
TranscriptomicsINO80 governs super-enhancer-mediated oncogenic transcription and tumor growth in melanoma [RNA-seq]
Super-enhancers (SEs) are large genomic regions with high density of enhancer marks. In cancer, SEs are found near oncogenes and dictate cancer gene expression. However, how oncogenic SEs are regulated remains poorly understood. Here, we show that INO80, a chromatin remodeling complex, is required f...
ORGANISM(S): Homo sapiens 
2016-07-07 | E-GEOD-82333 | biostudies-arrayexpress
GenomicsINO80 governs super-enhancer-mediated oncogenic transcription and tumor growth in melanoma [ATAC-seq]
Super-enhancers (SEs) are large genomic regions with high density of enhancer marks. In cancer, SEs are found near oncogenes and dictate cancer gene expression. However, how oncogenic SEs are regulated remains poorly understood. Here, we show that INO80, a chromatin remodeling complex, is required f...
ORGANISM(S): Homo sapiens 
2016-07-07 | E-GEOD-82330 | biostudies-arrayexpress
TranscriptomicsINO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer [RNA-seq]
Epigenetic regulators are attractive targets for the development of new cancer therapies. Among them, the ATP-dependent chromatin remodeling complexes control the chromatin architecture and play important roles in gene regulation. They are often found to be mutated and de-regulated in cancers, but h...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-85118 | biostudies-arrayexpress
GenomicsINO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer [ChIP-seq]
Epigenetic regulators are attractive targets for the development of new cancer therapies. Among them, the ATP-dependent chromatin remodeling complexes control the chromatin architecture and play important roles in gene regulation. They are often found to be mutated and de-regulated in cancers, but h...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-85117 | biostudies-arrayexpress
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