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MetabolomicsSemen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredi...

2025-05-12 | MTBLS11688 | MetaboLights
ProteomicsQuantitative phosphoproteomics explain cryopreservation-induced reductions in ram sperm motility
Our objective was to use quantitative phosphoproteomics for systematic comparative analyses of fresh versus frozen-thawed sperm to identify factors causing cryo-injury.
ORGANISM(S): Ovis Aries 
2023-12-28 | PXD048166 |
ProteomicsMulti-Omics Analysis Reveals Molecular Disruption in Mouse Testes Following Cumulative heat stress
Rising global temperatures threaten male fertility, yet the molecular mechanisms by which heat stress disrupts spermatogenesis remain incompletely understood. We employed an integrative multi-omics approach incorporating transcriptomics, proteomics, and metabolomics to examine the impact of sub-leth...
ORGANISM(S): Mus Musculus 
2026-02-26 | PXD074923 |
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