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TranscriptomicsEffect of BMP4 and noggin on gene expression in murine R1 ES cells
To confirm that the SMAD1/5- and SMAD4-associated genes are direct transcriptional regulators in mESCs in response to BMP, we treated undifferentiated R1 ES cells with BMP4 or with the BMP4 antagonist noggin, which can inhibit BMP signaling effectively for 4 h. Undifferentiated R1 ES cells were trea...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-20527 | biostudies-arrayexpress
UnknownA new novel mutation in FBN1 causes autosomal dominant Marfan syndrome in a Chinese family.
Not available
S-EPMC3261084 | biostudies-literature
ProteomicsTandem mass tag-based quantitative proteomic analysis reveals proteins involved in hemolytic hyperbilirubinemia-induced brain injury in rats
Hemolytic hyperbilirubinemia-induced brain injury (HHIBI) can cause neonatal death, and survivors often have neurological sequelae, including irreversible motor sensitive and cognitive abnormalities. However, the underlying mechanisms remain elusive. By identifying differentially abundant proteins (...
ORGANISM(S): Rattus Rattus 
2023-04-18 | PXD041604 |
Proteomicshepatocellular carcinoma proteomics
A DIA proteome analysis on HCC tissue (CA) and adjacent non-tumorous tissue (NO) samples
ORGANISM(S): Homo Sapiens 
2020-10-14 | PXD021979 |
ProteomicsThe proteome of chilli pepper stem during Sclerotium rolfsii Infection
In order to further understand the corresponding mechanism of pepper plants in different infection stages.The blocks of fungal mycelia were inoculated on the soil surface about 2 cm away from the base of stem of the pepper plants at the six-leaf stage. After getting rid of the hyphae on stem surface...
ORGANISM(S): Capsicum Annuum 
2021-10-27 | PXD029372 |
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
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