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TranscriptomicsMechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch
Hypoxia-induced cell injury has been related to multiple pathological conditions. In order to render hypoxia-sensitive cells and tissues resistant to low O2 environment, in this current study, we used Drosophila melanogaster as a model to dissect the mechanisms underlying hypoxia-tolerance. A D. mel...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-8803 | biostudies-arrayexpress
Genomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [Drug-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55901 | biostudies-arrayexpress
Transcriptomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [GRO-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55903 | biostudies-arrayexpress
ProteomicsPVF proteome of three Ampullariidae snails
Egg PVF proteins have been the primary focus in the water-to-land transition of ampullariids over the last three decades, but there is a lack of PVF data in Old-World species. To better understand the function and evolutionary history of PVF proteins, we generated Old-World Pila and Lanistes PVF pro...
ORGANISM(S): Pomacea canaliculata Pila pesmei Lanistes nyassanus 
2026-09-07 | PXD070092 | Pride
Pvf protein Lanistes nyassanus Pila pesmei Pomacea canaliculata 
TranscriptomicsCpG islands recruit a histone H3 lysine 36 demethylase [Agilent data]
Transcription factors that bind small DNA motifs embedded in promoters play a central role in controlling gene expression. However, in addition to these elements, up to 70% of genes in higher eukaryotes also have high levels of non-methylated cytosine/guanine base pairs (CpGs) surrounding promoters ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21201 | biostudies-arrayexpress
GenomicsCpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data]
Eukaryotic gene expression profiles are largely defined by transcription factors that recognize specific DNA sequences in gene regulatory regions and impact RNA polymerase recruitment and transcription. In addition to specific core promoter regulatory elements, up to 70% of genes in higher eukaryote...
ORGANISM(S): Mus musculus 
2010-04-27 | E-GEOD-18588 | biostudies-arrayexpress
UnknownSequential combination of decitabine and idarubicin synergistically enhances anti-leukemia effect followed by demethylating Wnt pathway inhibitor promoters and downregulating Wnt pathway nuclear target.
Not available
S-EPMC4082426 | biostudies-literature
Genomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55904 | biostudies-arrayexpress
UnknownChromosome-level genome assembly of Tibetan macaque ( Macaca thibetana) and species-specific structural variations.
Not available
S-EPMC9486518 | biostudies-literature
UnknownGenetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
Not available
S-EPMC4767461 | biostudies-literature
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