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MetabolomicsUPLC-Q-TOF/MS-Based Plasma and Urine Metabolomics Contribute to the Diagnosis of Sepsis
In this study, we aimed to identify potential metabolic biomarkers that can improve the diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis patients from an intensive care unit were recruited. The global plasma and urine metabolomic profiles were determined by ultr...
2023-04-18 | MTBLS3505 | MetaboLights
UnknownKun-Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile.
Not available
S-EPMC12359510 | biostudies-literature
MetabolomicsUltraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics and Lipidomics Identify Biomarkers for Efficacy Evaluation of Mesalazine in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model
This study aims to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis by metabolomics and lipidomics. A dextran sulfate sodium-induced mouse model was used. The disease status was assessed by a disease activity index, the TNF-α level of colon was measured...
2022-10-24 | MTBLS2111 | MetaboLights
ProteomicsMulti-Omic Signatures of Thyroid Damage in Age-Related Subclinical Hypothyroidism
Age-associated subclinical hypothyroidism (AR-SCH) causes severe structural and functional damage to thyroid glands in aged populations, but the global molecular mechanisms governing AR-SCH pathogenesis are largely unclear. We constructed an exhaustive multi-omic map of thyroid tissues from AR-SCH m...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-28 | PXD080737 | Pride
Subclinical hypothyroidism Mouse Proteomics Multi-omics 
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
GenomicsGenome-wide survey of YY1 targets in C2C12 cells by High-throughput sequencing
By applying ChIP-seq, we generated genome-wide maps of YY1 in skeletal myoblasts and myotubes. We found that YY1 binds to 1820 confident target with a large portion residing in the intergenic regions. In addition, YY1 was found to activate many loci, and there is no significant overlap between YY1 a...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-45875 | biostudies-arrayexpress
TranscriptomicsThe plasma membrane NADPH oxidase OsRbohA plays a crucial role in developmental regulation and drought-stress response in rice
Plasma membrane NADPH oxidases (NOXs) are major producers of reactive oxygen species (ROS) in plant cells under normal growth and stress conditions. Rice NOXs have multiple homologs but their functional mechanisms are largely unknown. We used microarrays to detail the global gene expression profiles...
ORGANISM(S): Oryza sativa Japonica Group 
2015-12-31 | E-GEOD-54466 | biostudies-arrayexpress
ProteomicsDivergent mitochondrial responses and metabolic signal pathways secure the azole resistance in Crabtree-positive and negative Candida species
we performed mitochondrial proteomic analysis on multiple Candida species (C. albicans, C. glabrata, C. krusei and Candida auris) and analyzed the differentially expressed mitochondrial proteins (DEMPs) between azole-sensitive and azole-resistant Candida species.
ORGANISM(S): Fungal Sp. Nt-01 
2023-09-05 | PXD045101 |
ProteomicsBiophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors
Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors
ORGANISM(S): Homo Sapiens 
2021-10-29 | PXD029445 |
ProteomicsComparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach
In this study, unstimulated saliva samples were collected from 30 children (age 10-12 years) with no dental caries (NDC, n=10), low dental caries (LDC, n=10), and high dental caries (HDC, n=10). Salivary proteins were extracted, reduced, alkylated, trypsin digested and labeled with isobaric tags for...
ORGANISM(S): Homo Sapiens 
2017-12-19 | PXD008488 |
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