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ProteomicsRegulation of the Endocytosis and Prion Chaperoning Machineries by Yeast E3 Ubiquitin Ligase Rsp5 as Revealed by Orthogonal Ubiquitin Transfer
Attachment of the ubiquitin (UB) peptide to proteins via the E1-E2-E3 enzymatic machinery regulates diverse biological pathways, yet identification of the substrates of E3 UB ligases remains a challenge. We overcame this challenge by constructing an “orthogonal UB transfer (OUT) cascade with yeast E...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-13 | PXD023688 | Pride
Ubiquitin Lc-ms/ms 
TranscriptomicsA genomic approach to bud mutation in sweet orange (Citrus sinensis L. Osbeck) fruit
Bud mutations arise often in citrus. The selection of mutants is one of the most important breeding methods in citrus. However, the molecular bases of bud mutation have rarely been studied. To identify the potential important or novel genes involved in bud mutation, different transcriptomic techniqu...
ORGANISM(S): Citrus sinensis 
2009-03-09 | E-GEOD-10729 | biostudies-arrayexpress
UnknownHepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance.
Not available
S-EPMC5434661 | biostudies-literature
TranscriptomicsMicroarray skeletal muscle miR-499 overexpressing mice
This experiment was conducted to identify target genes of the microRNA-499 in skeletal muscle of transgenic mice that overexpressed miR-499. The following abstract from the submitted manuscript describes the major findings of this work. Coupling of mitochondrial function and skeletal muscle f...
ORGANISM(S): Mus musculus 
2016-09-03 | E-GEOD-72581 | biostudies-arrayexpress
UnknownGenetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study.
Not available
S-EPMC10523972 | biostudies-literature
UnknownTwo new hypogean species of the genus Triplophysa (Osteichthyes, Cypriniformes, Nemacheilidae) from Guizhou Province, Southwest China, with underestimated diversity.
Not available
S-EPMC11484637 | biostudies-literature
MetabolomicsUPLC-Q-TOF/MS-Based Plasma and Urine Metabolomics Contribute to the Diagnosis of Sepsis
In this study, we aimed to identify potential metabolic biomarkers that can improve the diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis patients from an intensive care unit were recruited. The global plasma and urine metabolomic profiles were determined by ultr...
2023-04-18 | MTBLS3505 | MetaboLights
MetabolomicsSymbiotic bacteria-derived organic acids protect Delia antiqua larvae from entomopathogenic fungal infection

The protection of associated microbiota for their animal hosts against pathogen infection has been studied widely over the last 100 years. However, how those microbes protect the animal host is limitedly investigated. In former studies, body surface microbes of one insect, Delia antiqua,...

2020-11-12 | MTBLS2074 | MetaboLights
TranscriptomicsDNA Methylation Mediated by a MicroRNA Pathway
In plants, the known microRNAs (miRNAs) are produced as ~21 nucleotide (nt) duplexes from their precursors by Dicer like 1 (DCL1). They are incorporated into Argonaute 1 (AGO1) protein to regulate target gene expression primarily through mRNA cleavage. We report here the discovery of a new class of ...
ORGANISM(S): Oryza sativa 
2010-03-12 | E-GEOD-20748 | biostudies-arrayexpress
Proteomicsto screen the Treg inhibitor and investigate its mechanism in tumor
No Treg-specific therapeutics has been approved for clinical use. Our project aim to screen the Treg inhibitor and investigate its mechanism in tumor.
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD059236 | Pride
Human ip-ms runx1 
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