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TranscriptomicsOsJMJ705 preferentially activates stress-responsive genes
Histone methylation is important epigenomic information for gene regulation and genome activity To evaluate genome-wide effect of OsJMJ705 on gene expression, we used the Affymetrix microarray technologies to analyze the transcriptomes of the wild type, over-expression plants and the T-DNA mutant. ...
ORGANISM(S): Oryza sativa Japonica Group 
2013-12-10 | E-GEOD-48069 | biostudies-arrayexpress
UnknownTFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity.
Not available
S-EPMC11071895 | biostudies-literature
ProteomicsSpatial phosphoproteomics reveals phosphorylation features in liver cirrhosis
Liver cirrhosis (LC) is the end stage of chronic liver disease, characterized by pseudolobule formation and extensive fibrosis, with unclear regional dynamics of protein phosphorylation. This study used spatial phosphoproteomics combined with bioinformatics to analyze phosphorylation patterns in LC ...
ORGANISM(S): Homo Sapiens 
2025-11-21 | PXD071108 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsProteome, lysine acetylome and succinylome identify post-translational modification of STAT1 as a novel drug target in silicosis
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of...
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049146 |
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