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ProteomicsIn-cell isotope-coded labeling and LC-MS/MS analysis probe warfarin inhibition mechanism
Warfarin targets human vitamin K epoxide reductase (hVKOR), a redox enzyme in the membrane of endoplasmic reticulum (ER), to prevent the formation of blood clots. Although warfarin has been a popular medication since 1954, its mechanism of action is still unclear. A fundamental issue is the controve...
ORGANISM(S): Homo sapiens (Human) 
2017-03-30 | PXD003774 | Pride
Human vitamin k epoxide reuctase N-ethylmeleimide Isotope Bottom-up proteomics Warfarin 
ProteomicsInvestigation of circulating proteomic biomarkers for diagnosis of sporadic Amyotrophic Lateral Sclerosis
To reveal candidate biomarkers for sALS, serum sampled of 10 sALS patients and 5 healthy controls were collected and underwent label-free quantitative proteomics.
ORGANISM(S): Homo Sapiens 
2022-12-01 | PXD038507 |
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