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To review the potential molecular mechanism of the irreversible part of opacification under cold stimulation, we applied comparative transcriptomic and proteomic analysis to systematically investigate the molecular changes that occurred in the lens capsules of rats under low temperature treatments.
ORGANISM(S): Rattus Norvegicus 
Molecular analyses—including RNA immunoprecipitation, pull-down assays, mass spectrometry, and chromatin immunoprecipitation sequencing—demonstrated that RSDR and hnRNPK stabilize each other, forming a positive feedback loop that amplifies DHODH expression.
ORGANISM(S): Mus Musculus 
2025-03-19 | PXD062047 |
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