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ProteomicsLC-MS/MS for harmaline-treated mice cerebellar cortex
Harmaline-induced tremor mice model has been well-recognized as a mature pharmacological model for ET, but his model has always been used to test drugs, the exact underlying mechanism of this mouse model has never been fully understood. This project is to provide a novel inspection for ET targeted t...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-05 | PXD055985 | Pride
Cerebellar cortex Harmaline Mice Lc-ms/ms 
MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
ProteomicsFunctional Optic Tract Rewiring via Subtype- and Target-specific Axonal Regeneration and Presynaptic Activity Enhancement
We showed that with genetic manipulation as Pten/Socs3 knockout (KO), CNTF overexpression and Lipin1 knockdown (PSCL), RGCs could regenerate and reinnervate into OPN nuclei after pre-OPN optic tract injury. We then performed single-cell RNA sequencing on OPN-projecting retinal ganglion cells and pro...
ORGANISM(S): Mus Musculus 
2024-05-25 | PXD052573 |
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