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TranscriptomicsFoxo1/3 depletion in granulosa cells reveals novel mechanisms controlling follicle growth and death and endocrine regulation of pituitary FSH.
The Foxo transcription factors regulate multiple cellular functions. Foxo1 and Foxo3 are highly expressed in granulosa cells of ovarian follicles. Selective depletion of the Foxo1 and Foxo3 genes in granulosa cells revealed a novel ovarian-pituitary endocrine feedback loop characterized by: 1) undet...
ORGANISM(S): Mus musculus 
2013-02-16 | E-GEOD-35593 | biostudies-arrayexpress
TranscriptomicsFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development
The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cel...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67662 | biostudies-arrayexpress
TranscriptomicsGENE EXPRESSION ALTERATIONS IN ADULT UTP14b (jsd) MICE BY CONDITIONAL KNOCKOUT OF ANDROGEN RECEPTOR IN SERTOLI CELLS
Spermatogenesis is dependent primarily on testosterone action on the Sertoli cells. Although the identification of testosterone-regulated target genes in Sertoli cells has been approached using microarray analysis to compare gene expression in mice with androgen receptor (AR) elimination in the Ser...
ORGANISM(S): Mus musculus 
2010-09-06 | E-GEOD-20918 | biostudies-arrayexpress
ProteomicsUnveiling EMC6 as a Novel Pathogenic Determinant in hepatocellular carcinoma: Orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13
The endoplasmic reticulum (ER) membrane protein complex (EMC) is an ER multiprotein complex that affects a wide range of pathophysiological processes. Recently, the function of EMC6, a subunit of EMC, has been attracting attention for its role in cancers. However, research on EMC6 in the context of ...
ORGANISM(S): Mus Musculus 
PXD067920 |
Proteomicsproteome response to drought stress in different sweetpotato cultivars
A greenhouse pot experiment was conducted at experimental station. Drought treatment was conducted after transplanting for 10 days. seedlings were subjected to stress for about 20 days withholding irrigation until SMC was reduced to around 8%. The third full expanded leaves from the top were used fo...
ORGANISM(S): Dioscorea Esculenta 
2021-09-08 | PXD028232 |
ProteomicsCAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies
HIV-1 latency is a major obstacle to achieve a functional cure for AIDS. To eradicate the viral reservoir, one of the strategies is to specifically reactivate HIV-1-infected cells and followed by elimination with potent immune surveillance. However, present latency-reversing agents (LRAs) are quite ...
ORGANISM(S): Homo Sapiens 
2021-02-09 | PXD024172 |
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