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TranscriptomicsSingle-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms
Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we established an expe...
ORGANISM(S): Homo sapiens 
2021-06-16 | E-MTAB-7334 | biostudies-arrayexpress
TranscriptomicsLoss of the yeast SR protein Npl3 alters gene expression due to transcription readthrough
Yeast Npl3 is a highly abundant RNA binding protein, related to metazoan SR proteins, with reported functions including transcription elongation, splicing and RNA 3’ end processing. To identify direct targets and functions for Npl3, we used UV crosslinking and analysis of cDNA (CRAC) to map precise ...
ORGANISM(S): Saccharomyces cerevisiae S288c 
2015-12-02 | E-MTAB-3642 | biostudies-arrayexpress
Transcriptomicsset2 buratowski lab
H3K36 methylation by Set2 targets Rpd3S histone deacetylase to 3’ transcribed regions, repressing internal cryptic promoters and slowing elongation. To further explore the function of this pathway, global transcription was analyzed in yeast experiencing a series of carbon source shifts. Many pr...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-25 | E-MTAB-4268 | biostudies-arrayexpress
TranscriptomicsEnvironmentally persistent genetic associations with gene expression reveal pathways mediating genetic signals to phenotype
Unraveling the causal chain of biochemical events that link genotype to phenotype is critical for understanding the molecular basis of genetic diseases and for designing personalized drug therapies. To this end, using yeast as a model system, we carried out joint profiling of fitness and gene expres...
ORGANISM(S): Saccharomyces cerevisiae 
2013-08-12 | E-MTAB-1398 | biostudies-arrayexpress
TranscriptomicsControl of Cdc28 CDK1 by a stress-induced lncRNA
Genomic analysis has revealed the existence of a large number of long non-coding RNAs (lncRNAs) in a variety of organisms, including yeast. lncRNAs might have several biological functions during normal cell growth and development. Cells are subject to dramatic changes of gene expression in response ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-18 | E-MTAB-1686 | biostudies-arrayexpress
TranscriptomicsRoad-block transcription termination by Reb1p enforces transcription boundaries
Widely transcribed and compact genomes face the major challenge of coping with frequent overlapping or concurrent transcription events. Efficient and timely transcription termination is crucial to control pervasive transcription. In yeast, RNA polymerase II (RNAPII) termination mainly occurs via two...
ORGANISM(S): Saccharomyces cerevisiae 
2014-12-05 | E-MTAB-2241 | biostudies-arrayexpress
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