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ProteomicsProteomic analysis of the invasiveness of human bladder cancer cells
To identification of key drivers involved in the development of muscle invasive bladder cancer, which displays poor prognosis, we isolated one subpopulation of human 5637 bladder cancer cells with highly invasiveness and the other subpopulation of 5637 cells with low invasiveness by Transwell method...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-27 | MSV000082854 | MassIVE
ProteomicsIntegrated proteome and phosphoproteome analysis of interscapular brown adipose and subcutaneous white adipose tissues upon high fat diet feeding in mouse
Thermogenesis is a promising approach to limit weight gain in response to excess nutrition. In contrast to cold-induced thermogenesis, the molecular and cellular mechanisms of diet-induced thermogenesis (DIT) have not been fully characterized. Here, we explored the response of brown adipose tissue (...
ORGANISM(S): Mus Musculus 
2022-04-01 | PXD032888 |
ProteomicsOnline alkaline-pH reverse phase nanoelectrospray-tandem mass spectrometry complements conventional low-pH method for global proteomic analysis
The global proteome analysis was limited by the identification of peptides with low abundance or specific physiochemical properties. Here, a one-dimensional online alkaline-pH reverse phase nanoelectrospray-tandem mass spectrometry (AlkalinepH-MS/MS) method was developed and optimized for global pro...
ORGANISM(S): Homo Sapiens 
2023-01-15 | PXD039453 |
ProteomicsQuantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting PDGFRβ/PI3K/AKT pathway
Yinchenzhufu decoction (YCZFD) is a traditional Chinese medicine formula with hepatoprotective effects. In this study, the protective effects of YCZFD against cholestatic liver fibrosis and its mechanisms of action were evaluated in a mouse model of 3,5-diethoxycarbonyl-1,4-dihydro-collidine (DDC)-i...
ORGANISM(S): Mus Musculus 
PXD046101 |
ProteomicsMultiplexed Proteome Profiling of Targeted Protein Degradation With Data-Independent Acquisition-Based Mass Spectrometry
Targeted protein degradation (TPD) has become a powerful and promising tool that can effective trigger the degradation of specific disease-related proteins utilizing the endogenous pathways of the organism. However, the global proteomic profiling of TPD with multiple dimensions remains lacking since...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-03-06 | PXD050426 |
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD027958 |
ProteomicsProteomic analysis reveals molecular heterogeneity of adjacent-to-tumor samples in hepatocellular carcinoma
A DIA-MS dataset of 106 samples including 14 healthy liver tissues, 46 pairs of tumor and adjacent-to-tumor samples.
ORGANISM(S): Homo Sapiens 
2022-08-12 | PXD036048 |
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